Bioerodible Wraps and Uses Therefor

Abstract

A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.

1 .- 222 . (canceled) 
     
     
         223 . A tubular tissue graft device comprising:
 a living tubular tissue harvested from a patient having a wall defining a lumen, the lumen extending from a first end of the living tubular tissue to a second end of the living tubular tissue, the wall having an exterior surface; and   an electrospun fiber matrix deposition comprising a polymer, the electrospun fiber matrix deposition surrounding the exterior surface of the living tubular tissue,   wherein the electrospun fiber matrix deposition is configured to biodegrade over a period of from about two months to about one year.   
     
     
         224 . The tubular tissue graft device according to  claim 223 , wherein the electrospun fiber matrix deposition is configured to biodegrade over a period of from about two months to about six months. 
     
     
         225 . The tubular tissue graft device according to  claim 223 , wherein the electrospun fiber matrix deposition comprises a non-linear biodegradation rate. 
     
     
         226 . The tubular tissue graft device according to  claim 223 , wherein the electrospun fiber matrix deposition surrounds the exterior surface of the living tubular tissue from the first end to the second end of the living tubular tissue. 
     
     
         227 . The tubular tissue graft device according to  claim 223 , wherein the electrospun fiber matrix deposition comprises a thickness that varies along at least a portion of a length of the tubular tissue graft device. 
     
     
         228 . The tubular tissue graft device according to  claim 223 , wherein the living tubular tissue comprises a vein. 
     
     
         229 . The tubular tissue graft device according to  claim 223 , wherein the living tubular tissue comprises a saphenous vein. 
     
     
         230 . The tubular tissue graft device according to  claim 223 , wherein the living tubular tissue comprises tissue selected from the group consisting of: vein; artery; urethra; intestine; esophagus; ureter; trachea; bronchi; fallopian tube; and any combination thereof. 
     
     
         231 . The tubular tissue graft device according to  claim 223 , further comprising a scaffold disposed relative to the electrospun fiber matrix deposition and surrounding the exterior surface of the living tubular tissue. 
     
     
         232 . The tubular tissue graft device according to  claim 231 , wherein the scaffold surrounds the exterior surface of the living tubular tissue from the first end to the second end of the living tubular tissue. 
     
     
         233 . The tubular tissue graft device according to  claim 231 , wherein the exterior surface of the living tubular tissue defines a circumference, and wherein the scaffold surrounds the circumference of the living tubular tissue. 
     
     
         234 . The tubular tissue graft device according to  claim 231 , wherein the scaffold surrounds the electrospun fiber matrix deposition. 
     
     
         235 . The tubular tissue graft device according to  claim 231 , wherein the scaffold is positioned between the living tubular tissue and the electrospun fiber matrix deposition. 
     
     
         236 . The tubular tissue graft device according to  claim 231 , wherein the scaffold has at least one of a mesh structure, a coil structure, a braided structure, or a knitted structure. 
     
     
         237 . The tubular tissue graft device according to  claim 231 , wherein the scaffold has a stent-like construction. 
     
     
         238 . The tubular tissue graft device according to  claim 231 , wherein the scaffold comprises a first material and the electrospun fiber matrix deposition comprises a second material. 
     
     
         239 . The tubular tissue graft device according to  claim 231 , wherein the scaffold comprises a biodegradable material. 
     
     
         240 . The tubular tissue graft device according to  claim 231 , wherein the scaffold is configured to provide a radial supporting force to the living tubular tissue, the radial supporting force having a magnitude capable of changing over time. 
     
     
         241 . The tubular tissue graft device according to  claim 231 , wherein the scaffold comprises at least one of a resiliently biased portion, a plastically deformable portion, and a combination thereof. 
     
     
         242 . The tubular tissue graft device according to  claim 231 , wherein the scaffold is configured to provide an anchoring mechanism for the tubular tissue graft device.