Method for the improvement of mesh implant biocompatibility

Abstract

The present invention provides a method of fixating a mesh implant to a tissue of a subject comprising attaching said mesh implant to said tissue, covering said mesh implant by an antiadhesive barrier, wherein said antiadhesive barrier is attached to said mesh implant by a biocompatible adhesive.

1 . A method of fixating a barrier to a tissue of a subject comprising attaching the barrier to the tissue, wherein:
 (a) a biocompatible adhesive is applied onto the tissue in an open incision or by laparoscopy;   (b) the biocompatible adhesive comprises at least two components, which are either premixed and applied or mixed upon application; and   (c) the barrier is applied to the biocompatible adhesive.   
     
     
         2 . The method of  claim 1 , wherein the biocompatible adhesive is applied by spraying. 
     
     
         3 . The method of  claim 1 , wherein the biocompatible adhesive comprises fibrinogen and thrombin. 
     
     
         4 . The method of  claim 1 , wherein the barrier is a bioresorbable barrier. 
     
     
         5 . The method of  claim 1 , wherein the barrier is a sponge. 
     
     
         6 . The method of  claim 1 , wherein the barrier comprises a biopolymer. 
     
     
         7 . The method of  claim 1 , wherein the biocompatible adhesive is applied onto the tissue in an open incision, and the biocompatible adhesive comprises fibrinogen and thrombin, which are premixed. 
     
     
         8 . The method of  claim 1 , wherein the biocompatible adhesive is applied onto the tissue by spraying in an open incision, and the biocompatible adhesive comprises fibrinogen and thrombin, which are premixed. 
     
     
         9 . A method of fixating a barrier to a tissue of a subject comprising attaching the barrier to the tissue, wherein:
 (a) a biocompatible adhesive is applied onto the barrier   (b) the biocompatible adhesive comprises at least two components, which are either premixed and applied or mixed upon application; and   (c) the barrier having the biocompatible adhesive thereon is applied to the tissue in an open incision or by laparoscopy.   
     
     
         10 . The method of  claim 9 , wherein the biocompatible adhesive comprises fibrinogen and thrombin. 
     
     
         11 . The method of  claim 9 , wherein the barrier is a bioresorbable barrier. 
     
     
         12 . The method of  claim 9 , wherein the barrier is a sponge. 
     
     
         13 . The method of  claim 9 , wherein the barrier comprises a biopolymer. 
     
     
         14 . The method of  claim 9 , wherein the biocompatible adhesive comprises fibrinogen and thrombin, which are premixed, and the barrier having the biocompatible adhesive thereon is applied to the tissue in an open incision. 
     
     
         15 . A kit comprising: a biocompatible adhesive; and instructions for use of the kit, wherein the biocompatible adhesive comprises at least two components, which are either premixed and applied or mixed upon application, and wherein the instructions recite that
 (i) the biocompatible adhesive is to be applied onto a tissue in an open incision or by laparoscopy; and   (ii) a barrier is to be applied to the biocompatible adhesive.   
     
     
         16 . The kit of  claim 15 , wherein the biocompatible adhesive is to be applied by spraying. 
     
     
         17 . The kit of  claim 15 , wherein the biocompatible adhesive comprises fibrinogen and thrombin. 
     
     
         18 . The kit of  claim 15 , wherein the barrier is a bioresorbable barrier. 
     
     
         19 . The kit of  claim 15 , wherein the barrier is a sponge. 
     
     
         20 . The kit of  claim 15 , wherein the barrier comprises a biopolymer. 
     
     
         21 . The kit of  claim 15 , wherein the biocompatible adhesive is to be applied onto the tissue in an open incision, and the biocompatible adhesive comprises fibrinogen and thrombin, which are premixed. 
     
     
         22 . The kit of  claim 15 , wherein the biocompatible adhesive is to be applied onto the tissue by spraying in an open incision, and the biocompatible adhesive comprises fibrinogen and thrombin, which are premixed. 
     
     
         23 . The kit of  claim 15 , wherein the biocompatible adhesive is preapplied to the barrier. 
     
     
         24 . The kit according to  claim 15 , further comprising a biocompatible adhesive applicator configured to spray the biocompatible adhesive.