Nutritional compositions comprising sn-1 (3) monoacylglycerols for use in the treatment of malabsorption or maldigestion in infants or young children

Abstract

The present invention refers to nutritional composition comprising sn-1(3) monoacylglycerols for use in the treatment or prevention of maldigestion and/or malabsorption in an infant or young child. It also refers to a nutritional composition comprising sn-1(3) monoacylglycerols for use to increase lipid (e.g. fatty acids) absorption/delivery and/or to increase the energy or the mineral bioavailability in an infant or young child. The infant or young child may have a gut immaturity and/or a reduced enteral feeding tolerance. They may also be pretermand/or low birth weight.

1 . A method for the treatment or prevention of maldigestion and/or malabsorption in an infant or young child comprising administering a nutritional composition comprising sn-1(3) monoacylglycerols to an infant or young child in need of same. 
     
     
         2 . A method for use to increase lipid absorption and/or delivery, and/or to increase the energy or the mineral bioavailability in an infant or young child comprising administering a nutritional composition comprising sn-1(3) monoacylglycerols to an infant or young child in need of same. 
     
     
         3 . Method according to  claim 1  wherein the sn-1(3)-monoacylglycerol is selected from the group consisting of sn-1(3)-monohexadecanoylglycerol, sn-1(3)-monotetradecanoylglycerol, sn-1(3)-monoeicosatetraenoilglycerol, sn-1(3)-monooctadecanoylglycerol, sn-1(3)-monooctadecadienoylglycerol, sn-1(3)-monoeicosapentaenoylglycerol, sn-1(3)-monodocosahexaenoylglycerol, sn-1(3)-monooctadecatrienoylglycerol, sn-1(3)-monooctadecatetraenoylglycerol, sn-1(3)-monoeicosatrienoylglycerol, sn-1(3)-monodocosapentaenoylglycerol, sn-1(3)-monosciadonylglycerol, sn-1(3)-monojuniperonylglycerol and combinations thereof. 
     
     
         4 . Method according to  claim 1 , wherein the sn-1(3)-monoacylglycerol is selected from the group consisting of sn-1(3) monoeicosapentaenoylglycerol, sn-1(3)-monodocosahexaenoylglycerol, sn-1(3)-monoeicosatetraenoilglycerol, sn-1(3)-monooctadecadienoylglycerol, sn-1(3)-monooctadecatrienoylglycerol and combinations thereof. 
     
     
         5 . Method according to  claim 1 , wherein the sn-1(3) monoacylglycerol provides about 0.0001% to 100% of the energy of the nutritional composition. 
     
     
         6 . Method according to  claim 1  wherein the sn-1(3) monoacylglycerols comprises at least one functional fatty acid. 
     
     
         7 . Method according to  claim 6  wherein the functional fatty acid is selected from the group consisting of tetradecanoic acid (myristic acid), hexadecanoic acid (palmitic acid), octadecanoic acid (stearic acid), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), arachidonic acid (ARA), stearidonic acid, γ-linolenic acid (GLA), dihomo-γ-linolenic acid (DGLA), n-3 docosapentanenoic acid (DPA), sciadonic acid and juniperonic acid. 
     
     
         8 . Method according to  claim 1  wherein the sn-1(3) monoacylglycerols (MAG) comprise at least one of sn-1(3) MAG-EPA, sn-1(3) MAG-DHA, sn-1(3) MAG-LA, sn-1(3) MAG-ALA or sn-1(3) MAG-ARA. 
     
     
         9 - 10 . (canceled) 
     
     
         11 . Method according to  claim 1 , wherein the infant or young child has a gut immaturity and/or a reduced enteral feeding tolerance. 
     
     
         12 - 14 . (canceled) 
     
     
         15 . Method according to  claim 1 , wherein the nutritional composition is in a form selected from the group consisting of an infant formula, a starter infant formula, a follow-up or follow-on infant formula, a growing-up milk, a baby food, an infant cereal composition, a fortifier and a supplement. 
     
     
         16 . (canceled) 
     
     
         17 . Method according to  claim 2  wherein the sn-1(3)-monoacylglycerol is selected from the group consisting of sn-1(3)-monohexadecanoylglycerol, sn-1(3)-monotetradecanoylglycerol, sn-1(3)-monoeicosatetraenoilglycerol, sn-1(3)-monooctadecanoylglycerol, sn-1(3)-monooctadecadienoylglycerol, sn-1(3)-monoeicosapentaenoylglycerol, sn-1(3)-monodocosahexaenoylglycerol, sn-1(3)-monooctadecatrienoylglycerol, sn-1(3)-monooctadecatetraenoylglycerol, sn-1(3)-monoeicosatrienoylglycerol, sn-1(3)-monodocosapentaenoylglycerol, sn-1(3)-monosciadonylglycerol, sn-1(3)-monojuniperonylglycerol and combinations thereof. 
     
     
         18 . Method according to  claim 2 , wherein the sn-1(3)-monoacylglycerol is selected from the group consisting of sn-1(3) monoeicosapentaenoylglycerol, sn-1(3)-monodocosahexaenoylglycerol, sn-1(3)-monoeicosatetraenoilglycerol, sn-1(3)-monooctadecadienoylglycerol, sn-1(3)-monooctadecatrienoylglycerol and combinations thereof. 
     
     
         19 . Method according to  claim 2 , wherein the sn-1(3) monoacylglycerol provides about 0.0001% to 100% of the energy of the nutritional composition. 
     
     
         20 . Method according to  claim 2  wherein the sn-1(3) monoacylglycerols comprises at least one functional fatty acid. 
     
     
         21 . Method according to  claim 2  wherein the functional fatty acid is selected from the group consisting of tetradecanoic acid (myristic acid), hexadecanoic acid (palmitic acid), octadecanoic acid (stearic acid), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), arachidonic acid (ARA), stearidonic acid, γ-linolenic acid (GLA), dihomo-γ-linolenic acid (DGLA), n-3 docosapentanenoic acid (DPA), sciadonic acid and juniperonic acid. 
     
     
         22 . Method according to  claim 2  wherein the sn-1(3) monoacylglycerols (MAG) comprise at least one of sn-1(3) MAG-EPA, sn-1(3) MAG-DHA, sn-1(3) MAG-LA, sn-1(3) MAG-ALA or sn-1(3) MAG-ARA. 
     
     
         23 . Method according to  claim 2 , wherein the infant or young child has a gut immaturity and/or a reduced enteral feeding tolerance. 
     
     
         24 . Method according to  claim 2 , wherein the nutritional composition is in a form selected from the group consisting of an infant formula, a starter infant formula, a follow-up or follow-on infant formula, a growing-up milk, a baby food, an infant cereal composition, a fortifier and a supplement.