Alimentary Protein-Based Scaffolds (APS) for Wound Healing, Regenerative Medicine and Drug Discovery

Abstract

The invention provides engineered biomaterials derived from plant products. The engineered biomaterials are useful for biomedical applications. The engineered biomaterials are able to support the growth of animal calls.

1 - 30 . (canceled) 
     
     
         31 . A method of treating a wound in a subject, the method comprising contacting an electroprocessed composition comprising fibers of a plant product-derived biomaterial and a synthetic polymer to a subject in need thereof. 
     
     
         32 . The method of  claim 31 , wherein said electroprocessed is electrospun. 
     
     
         33 . The method of  claim 31 , wherein said plant product is from a plant selected from the group consisting of corn, wheat, potato, sorghums, tapioca, rice, arrow root, sago, soybean, pea, sunflower, peanut, gelatin, and any combination thereof. 
     
     
         34 . The method of  claim 31 , wherein said plant product is soy protein isolate. 
     
     
         35 . The method of  claim 31 , wherein said plant product is corn zein. 
     
     
         36 . The method of  claim 31 , wherein said composition is capable of supporting cell growth. 
     
     
         37 . The method of  claim 31 , wherein said composition is capable of supporting the maintenance of a differentiation state of a cell. 
     
     
         38 . The method of  claim 31 , further comprising a cell. 
     
     
         39 . The method of  claim 38 , wherein said cell is genetically modified. 
     
     
         40 . The method of  claim 31  further comprising a material selected from the group consisting of fibronectin, laminin, collagen, glycoprotein, thrombospondin, elastin, fibrillin, mucopolysaccharide, glycolipid, heparin sulfate, chondroitin sulfate, keratin sulfate, glycosaminoglycan, hyaluronic acid, proteoglycan, vitronectin, poly-D-lysine, polysaccharide, and any combination thereof. 
     
     
         41 . The method of  claim 31  further comprising an adhesive. 
     
     
         42 . The method of  claim 31 , wherein said synthetic material is selected from the group consisting of poly(epsilon-caprolactone) (PCL), poly(lactic acid) (PLA), poly(glycolic acid) (PGA), copolymers poly (lactide-co-glycolide) (PLGA), polyaniline, poly(ethylene oxide) (PEO), and any combination thereof.