Compositions and Methods for Transplantation of Colon Microbiota

Abstract

The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.

1 - 42 . (canceled) 
     
     
         43 . A method for preventing a recurrent  Clostridium difficile  infection in a patient in need thereof, said method comprising
 administering to said patient an effective amount of a human fecal microbe preparation derived from an unrelated and non-patient selected donor.   
     
     
         44 . The method of  claim 43 , wherein said administering is orally administering. 
     
     
         45 . The method of  claim 43 , wherein said patient experienced at least three previous  Clostridium difficile  infections prior to said administering. 
     
     
         46 . The method of  claim 43 , wherein said patient has an inflammatory bowel disease. 
     
     
         47 . The method of  claim 43 , wherein said patient is free of a recurrent  Clostridium difficile  infection for at least two months after said administering. 
     
     
         48 . The method of  claim 47 , wherein said patient tests negative for  Clostridium difficile  toxin B for at least two months after said administering. 
     
     
         49 . The method of  claim 47 , wherein said patient is free of a recurrent  Clostridium difficile  infection for at least three months after said administering. 
     
     
         50 . The method of  claim 43 , further comprising pretreating said patient with one or more antibiotics prior to said administering. 
     
     
         51 . The method of  claim 50 , wherein said one or more antibiotics are selected from the group consisting of Metroidazole, Rifaximin, Vancomycin, and Neomycin. 
     
     
         52 . The method of  claim 43 , wherein said human fecal microbe preparation is frozen. 
     
     
         53 . The method of  claim 43 , wherein said human fecal microbe preparation is lyophilized. 
     
     
         54 . The method of  claim 43 , wherein said human fecal microbe preparation consists essentially of particles capable of passing through a 0.5 mm sieve and an intestinal microbiota from said unrelated donor. 
     
     
         55 . The method of  claim 43 , wherein said human fecal microbe preparation comprises an extract of feces from said unrelated and non-patient selected donor. 
     
     
         56 . The method of  claim 43 , wherein said human fecal microbe preparation comprises at least 5×10 10  cells. 
     
     
         57 . The method of  claim 43 , wherein said unrelated and non-patient selected donor is not a friend or domestic partner of said patient. 
     
     
         58 . A method for preventing a relapse of a  Clostridium difficile  infection in a patient in need thereof, said method comprising
 administering to said patient an effective amount of a human fecal microbe preparation derived from an unrelated and non-patient selected donor.   
     
     
         59 . The method of  claim 58 , wherein said administering is orally administering. 
     
     
         60 . The method of  claim 58 , wherein said patient is free of a recurrent  Clostridium difficile  infection for at least three months after said administering. 
     
     
         61 . A method for treating a recurrent  Clostridium difficile  infection in a patient in need thereof, said method comprising
 orally administering to said patient an effective amount of a human fecal microbe preparation derived from an unrelated and non-patient selected donor.