Compounds and Methods for Modulating Vascular Injury

Abstract

Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving lipid mediators to modulate a biological activity of vascular smooth muscle cells (VSMC) or vascular endothelial cells (VEC). Pro-resolving lipid mediators that find use in the subject methods include derivatives of omega-3 polyunsaturated fatty acids and omega-6 polyunsaturated fatty acids, such as resolvins, protectins, lipoxins and maresins and their therapeutically stable analogs. Also provided are vascular devices and compositions for use in the subject methods. Such methods, devices and compositions find use in a variety of applications, including applications related to treatment of vascular injuries and vascular scarring (e.g., restenosis), and applications related to chronic inflammatory diseases of the vascular wall .

1 - 70 . (canceled) 
     
     
         71 . An article comprising:
 a substrate comprising at least one surface, and   a coating comprising a nanotube comprising nitinol,   wherein the coating is formed on the at least one surface of the substrate.   
     
     
         72 . The article of  claim 71 , wherein the substrate comprises a metal. 
     
     
         73 . The article of  claim 71 , wherein the substrate comprises a stainless steel, an alloy of cobalt and chromium, an alloy of nickel and titanium, or mixtures thereof. 
     
     
         74 . The article of  claim 71 , wherein the substrate comprises nitinol. 
     
     
         75 . The article of  claim 71 , wherein the substrate comprises electropolished nitinol. 
     
     
         76 . The article of  claim 71 , wherein diameter of the nanotube is in the range of 10 nanometer to 1,000 nanometers. 
     
     
         77 . The article of  claim 71 , wherein length of the nanotube is in the range of 100 nanometers to 100 micrometers. 
     
     
         78 . The article of  claim 71 , wherein the article comprises a medical device. 
     
     
         79 . The article of  claim 71 , wherein the article comprises a stent. 
     
     
         80 . An article comprising:
 a substrate comprising at least one surface, and   a coating comprising a nanotube,   wherein the coating is formed on the at least one surface of the substrate, wherein the substrate comprises nitinol.   
     
     
         81 . The article of  claim 80 , wherein the substrate comprises electropolished nitinol. 
     
     
         82 . The article of  claim 80 , wherein the nanotube comprises nitinol. 
     
     
         83 . The article of  claim 80 , wherein the nanotube comprises titania. 
     
     
         84 . The article of  claim 80 , wherein diameter of the nanotube is in the range of 10 nanometer to 1,000 nanometers. 
     
     
         85 . The article of  claim 80 , wherein length of the nanotube is in the range of 100 nanometers to 100 micrometers. 
     
     
         86 . The article of  claim 80 , wherein the article comprises a medical device. 
     
     
         87 . The article of  claim 80 , wherein the article comprises a stent.