Diazepinone derivatives

Abstract

The invention relates to compound of the formula I or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to its use as medicament and to medicaments comprising it.

1 . A compound of the formula I 
       
         
           
           
               
               
           
         
         or a salt thereof, wherein 
         A is a fused five- to seven-membered monocyclic ring system which may be aromatic, saturated or unsaturated non-aromatic and which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur; 
         R 1  is halogen; cyano; nitro; hydroxy; amino; —C(O)H; —C(O)NH 2 ; —X 1 —R 5 ; or —X 2 —B 2 ; 
         X 1  is selected from bond; carbonyl; oxygen; sulfur; —S(O)—; —S(O) 2 —; amino, which may be substituted by C 1-4 alkyl; —NH—C(O)—; —C(O)—NH—; —C(O)—O—; —O—C(O)—; —NH—S(O) 2 —; —S(O) 2 —NH—; and —NHC(O)NH—; 
         R 5  is C 1-6 alkyl; C 1-6 halogenalkyl; C 1-6 cyanoalkyl; C 1-6 carboxyalkyl; C 1-6 hydroxyalkyl; C 1-4  alkoxy-C 1-6 alkyl; C 1-4 alkoxy-C 1-4 alkoxy-C 1-6 alkyl; C 1-4 alkylcarbonyl-C 1-6 alkyl; C 1-4 alkoxycarbonyl-C 1-6 alkyl; C 1-4 alkylcarbonyloxy-C 1-6 alkyl; C 1-6 aminoalkyl; C 1-4 alkylamino-C 1-6 alkyl; di(C 1-4 alkyl)amino-C 1-6 alkyl; aminocarbonyl-C 1-6 alkyl; C 1-4 alkylaminocarbonyl-C 1-6 alkyl; di(C 1-4 alkyl)aminocarbonyl-C 1-6 alkyl; C 1-4 alkylcarbonylamino-C 1-6 alkyl; C 1-4 alkylaminosulfonyl-C 1-6 alkyl; di(C 1-4 alkyl)aminosulfonyl-C 1-6 alkyl; C 2-6 alkenyl; C 2-6 halogenalkenyl; C 2-6 alkinyl; C 2-6 halogenalkinyl; 
         X 2  is bond or C 1-3 alkylene, wherein one carbon atom of the C 1-3 alkylene may be replaced by a group selected from carbonyl; oxygen; sulfur; —S(O)—; —S(O) 2 —; amino, which may be substituted by C 1-4 alkyl; —NH—C(O)—; —C(O)—NH—; —C(O)—O—; —O—C(O)—; —NH—S(O) 2 —; —S(O) 2 —NH—; and —NHC(O)NH—; 
         B 2  is a three- to seven-membered monocyclic ring system which may be aromatic, saturated or unsaturated non-aromatic and which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may in turn be substituted once or more than once by R 6 ; 
         each R 6  independently is halogen, hydroxy, cyano, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4 alkoxy, or C 1-4 halogenalkoxy; or two R 6  at the same ring atom together are oxo; 
         m is 0, 1, 2, 3 or 4; 
         each R 2  independently is halogen, cyano, hydroxy, amino, C 1-4 alkyl; C 1-4 halogenalkyl; C 1-4  hydroxyalkyl; C 1-4 aminoalkyl; C 1-4 alkylamino-C 1-4 alkyl; di-(C 1-4 alkyl)amino-C 1-4 alkyl; C 1-4  alkoxy-C 1-4 alkyl; C 2-4 alkenyl; C 2-4 halogenalkenyl; C 2-4 alkinyl; C 2-4 halogenalkinyl; C 1-4 alkoxy; C 1-4 halogenalkoxy; C 1-4 alkyl-amino; di-(C 1-4 alkyl)amino or C 3-6 cycloalkyl, wherein one carbon atom of the C 3-6 cycloalkyl may be replaced by an oxygen atom and wherein the C 3-6 cycloalkyl may be attached directly to the ring system or via a C 1-2 alkylene or an oxygen; 
         n is 0, 1, 2, 3 or 4; 
         each R 3  independently is halogen, cyano, hydroxy, amino, C 1-4 alkyl; C 1-4 halogenalkyl; C 1-4  hydroxyalkyl; C 1-4 aminoalkyl; C 1-4 alkylamino-C 1-4 alkyl; di-(C 1-4 alkyl)amino-C 1-4 alkyl; C 1-4  alkoxy-C 1-4 alkyl; C 2-4 alkenyl; C 2-4 halogenalkenyl; C 2-4 alkinyl; C 2-4 halogenalkinyl; C 1-4 alkoxy; 
         C 1-4 halogenalkoxy; C 1-4 alkyl-amino; di-(C 1-4 alkyl)amino or C 3-6 cycloalkyl, wherein one carbon atom of the C 3-6 cycloalkyl may be replaced by an oxygen atom and wherein the C 3-6 cycloalkyl may be attached directly to the ring system or via a C 1-2 alkylene or an oxygen; 
         R 4  is hydrogen, halogen, cyano, hydroxy, amino, C 1-4 alkyl; C 1-4 halogenalkyl; C 1-4 hydroxyalkyl; C 1-4 aminoalkyl; C 1-4 alkylamino-C 1-4 alkyl; di-(C 1-4 alkyl)amino-C 1-4 alkyl; C 1-4 alkoxy-C 1-4 alkyl; C 2-4 alkenyl; C 2-4 halogenalkenyl; C 2-4 alkinyl; C 2-4 halogenalkinyl; C 1-4 alkoxy; C 1-4 halogenalkoxy; C 1-4 alkyl-amino; di-(C 1-4 alkyl)amino or C 3-6 cycloalkyl, wherein one carbon atom of the C 3-6 cycloalkyl may be replaced by an oxygen atom and wherein the C 3-6 cycloalkyl may be attached directly to the ring system or via a C 1-2 alkylene or an oxygen; 
         B 1  is a five- to six-membered aromatic ring system, which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may in turn be substituted once or more than once by R 7 ; 
         each R 7  independently is 
         halogen, cyano, hydroxy, amino, 
         C 1-4 alkyl; C 1-4 halogenalkyl; C 1-4 hydroxyalkyl; C 1-4 aminoalkyl; C 1-4 alkylamino-C 1-4 alkyl; di-(C 1-4  alkyl)amino-C 1-4 alkyl; C 1-4 alkoxy-C 1-4 alkyl; 
         C 2-4 alkenyl; C 2-4 halogenalkenyl; C 2-4 alkinyl; C 2-4 halogenalkinyl; 
         C 1-4 alkoxy; C 1-4 alkoxy-C 1-4 alkoxy C 1-4 halogenalkoxy; 
         C 1-4 alkyl-amino; di-(C 1-4 alkyl)amino; 
         C 1-4 alkoxycarbonyl; 
         or a three- to seven-membered monocyclic ring system which may be aromatic, saturated or unsaturated non-aromatic and which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may in turn be substituted once or more than once by R 8 ; 
         each R 8  independently is halogen, hydroxy, cyano, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4 alkoxy, or C 1-4 halogenalkoxy; or two R 8  at the same ring atom together are oxo; 
         or two R 7  at adjacent ring atoms atoms form together with said ring atoms a fused five- to seven-membered monocyclic unsaturated non-aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may in turn be substituted once or more than once by R 9 ; 
         each R 9  independently is halogen, hydroxy, cyano, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4 alkoxy, or C 1-4 halogenalkoxy; or two R 9  at the same ring atom together are oxo. 
       
     
     
         2 . A compound of formula I according to  claim 1 , wherein A is phenyl. 
     
     
         3 . A compound of formula I according to  claim 1 , wherein R 1  is —X 2 —B 2 , wherein X 2  is bond;
 B 2  is C 3-6 cycloalkyl which may be substituted once or more than once by R 6 ; 
 or B 2  is a five- to six-membered aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may in turn be substituted once or more than once by R 6 ; each R 6  independently is halogen, hydroxy, cyano, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4 alkoxy, or C 1-4 halogenalkoxy. 
 
     
     
         4 . A compound of formula I according to  claim 1 , wherein
 m is 0, 1 or 2;   each R 2  independently is halogen, C 1-4 alkyl; C 1-4 halogenalkyl; C 1-4 alkoxy; C 1-4 halogenalkoxy or C 3-6 cycloalkyl;   n is 0; and   R 4  is hydrogen.   
     
     
         5 . A compound of formula I according to  claim 1 , wherein B 1  is a five- to six-membered aromatic ring system, which contains from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may in turn be substituted once or more than once by R 7 ; and wherein each R 7  independently is halogen, C 1-4 alkyl; C 1-4 halogenalkyl; C 1-4 alkoxy-C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkoxy-C 1-4 alkoxy or C 3-6 cycloalkyl. 
     
     
         6 . A compound of formula I according to  claim 1 , wherein
 A is phenyl;   R 1  is —X 2 —B 2 , wherein X 2  is bond;   B 2  is C 3-6 cycloalkyl which may be substituted once or more than once by R 6 ;   or B 2  is a five- to six-membered aromatic ring system which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may in turn be substituted once or more than once by R 6 ;   each R 6  independently is halogen, hydroxy, cyano, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4 alkoxy, or C 1-4 halogenalkoxy;   m is 0, 1 or 2;   each R 2  independently is halogen, C 1-4 alkyl; C 1-4 halogenalkyl; C 1-4 alkoxy; C 1-4 halogenalkoxy or C 3-6 cycloalkyl;   n is 0, 1 or 2;   each R 3  independently is halogen, C 1-4 alkyl; C 1-4 halogenalkyl; C 1-4 alkoxy; C 1-4 halogenalkoxy or C 3-6 cycloalkyl;   R 4  is hydrogen, halogen, C 1-4 alkyl; C 1-4 halogenalkyl; C 1-4 alkoxy; C 1-4 halogenalkoxy or C 3-6 cycloalkyl;   B 1  is a five- to six-membered aromatic ring system, which contains from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system may in turn be substituted once or more than once by R 7 ;   and wherein each R 7  independently is halogen, C 1-4 alkyl; C 1-4 halogenalkyl; C 1-4 alkoxy-C 1-4  alkyl, C 1-4 alkoxy, C 1-4 alkoxy-C 1-4 alkoxy or C 3-6 cycloalkyl.   
     
     
         7 . A compound of formula I according to  claim 1 , wherein said compound is selected from the group consisting of
 9-methoxy-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-chloro-2-(thiophen-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-chloro-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(thiophen-2-yl)-9-(trifluoromethyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(thiophen-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-chloro-2-(2-methoxypyrid in-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(5-methylfuran-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(2-methoxypyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(6-methoxypyridin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(2-ethylpyridin-4-yl)-9-methoxy-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(1-methyl-1H-pyrazol-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(3-(2-methoxyethoxy)phenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   10-chloro-9-methoxy-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   11-chloro-9-methoxy-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-ethoxyphenyl)-9-methoxy-7-methyl-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(3-(trifluoromethyl)phenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(4-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(5-methoxy-2-methylphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-fluoro-2-(thiophen-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-bromo-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(2-(dimethylamino)pyridin-4-yl)-9-methoxy-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(2-methoxypyrid in-4-yl)-9-morpholino-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(5-methylfuran-2-yl)-9-morpholino-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(1-methyl-1H-pyrazol-3-yl)-9-morpholino-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(1-methyl-1H-pyrazol-4-yl)-9-morpholino-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(2-hydroxypropan-2-yl)-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(2-hydroxypropan-2-yl)-2-(1-methyl-1H-pyrazol-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(furan-2-yl)-9-(pyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-bromo-2-(thiophen-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-iodo-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-iodo-2-(1-methyl-1H-pyrazol-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-iodo-2-(1-methyl-1H-pyrazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-iodo-2-(2-methoxypyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(furan-3-yl)-9-iodo-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-iodo-2-(1-isopropyl-1H-pyrazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-iodo-2-(1-methyl-1H-imidazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-ethyl-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-ethynyl-2-(thiophen-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   5-oxo-2-(thiophen-2-yl)-4,5,7,8-tetrahydro-[1,4]diazepino[7,1-a]isoquinoline-9-carbonitrile;   2-(1-methyl-1H-pyrazol-3-yl)-5-oxo-4,5,7,8-tetrahydro-[1,4]diazepino[7,1-a]isoquinoline-9-carbonitrile;   2-(3-methoxyphenyl)-9-morpholino-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(1-isopropyl-1H-pyrazol-4-yl)-9-(1H-pyrazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-((dimethylamino)methyl)-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-((2-methoxyethoxy)methyl)-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(hydroxymethyl)-2-(1-methyl-1H-pyrazol-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(hydroxymethyl)-2-(1-methyl-1H-pyrazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(1-methoxyethyl)-2-(1-methyl-1H-pyrazol-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-acetyl-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-methoxyphenyl)-9-phenyl-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(2-methoxypyridin-4-yl)-9-(pyridin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(furan-3-yl)-9-(pyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(2-methoxypyridin-4-yl)-9-(pyrazin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(6-fluoropyridin-3-yl)-2-(2-methoxypyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(3-fluoropyridin-4-yl)-2-(2-methoxypyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(1-methyl-1H-imidazol-4-yl)-9-(pyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(1-methyl-1H-pyrazol-3-yl)-9-(2-methylpyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-methoxyphenyl)-9-(tetrahydrofuran-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one,   (R)-2-(3-methoxyphenyl)-9-(tetrahydrofuran-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (S)-2-(3-methoxyphenyl)-9-(tetrahydrofuran-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(6-oxo-1,6-dihydropyridin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9,10-dimethoxy-2-(3-methoxyphenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-methoxy-2-(2-oxo-1,2-dihydropyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-isopropyl-1H-imidazol-1-yl)-9-methoxy-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-chloro-2-(4-methyl-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-iodo-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   1-(9-iodo-5-oxo-4,5,7,8-tetrahydro-[1,4]diazepino[7,1-a]isoquinolin-2-yl)-1H-imidazole-4-carbonitrile;   2-(4-(hydroxymethyl)-1H-imidazol-1-yl)-9-iodo-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   methyl 1-(9-iodo-5-oxo-4,5,7,8-tetrahydro-[1,4]diazepino[7,1-a]isoquinolin-2-yl)-1H-imidazole-4-carboxylate;   2-(2,4-dimethyl-1H-imidazol-1-yl)-9-iodo-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   ethyl 1-(9-iodo-5-oxo-4,5,7,8-tetrahydro-[1,4]diazepino[7,1-a]isoquinolin-2-yl)-1H-imidazole-4-carboxylate;   2-(4-cyclobutyl-1H-imidazol-1-yl)-9-(1H-pyrazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclobutyl-1H-imidazol-1-yl)-9-morpholino-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(methoxymethyl)-1H-imidazol-1-yl)-9-(thiazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-isopropyl-1H-imidazol-1-yl)-9-(1-methyl-1H-pyrazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-isopropyl-1H-imidazol-1-yl)-9-(1-methyl-1H-imidazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-ethyl-1H-imidazol-1-yl)-9-(oxazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-ethyl-1H-imidazol-1-yl)-9-(furan-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(2-methoxyethyl)-1H-imidazol-1-yl)-9-(thiazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(methoxymethyl)-1H-imidazol-1-yl)-9-(5-methylthiazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-methyl-1H-imidazol-1-yl)-9-(pyrimidin-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-methyl-1H-imidazol-1-yl)-9-(pyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7, 1-a]isoquinolin-5(4H)-one;   2-(4-methyl-1H-imidazol-1-yl)-9-(pyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(6-fluoropyridin-3-yl)-2-(4-methyl-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-methyl-1H-imidazol-1-yl)-9-(thiazol-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-chloro-1H-imidazol-1-yl)-9-(5-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(6-fluoropyridin-3-yl)-2-(4-(2-methoxyethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(methoxymethyl)-1H-imidazol-1-yl)-9-vinyl-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-ethyl-1H-imidazol-1-yl)-9-(4-fluorophenyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(4-methyloxazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(5-methyloxazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(oxazol-2-yl)-1H-imidazol-1-yl)-9-propyl-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-ethyl-2-(4-isopropyl-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-methyl-1H-imidazol-1-yl)-9-propyl-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclobutyl-2-(4-(methoxymethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclobutyl-2-(3-methyl-1H-1,2,4-triazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(3-(methoxymethyl)-1H-1,2,4-triazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   4-(6-fluoropyridin-3-yl)-1H-(4-isopropyl-1H-imidazol-1-yl)-5,6-dihydro-[1,4]diazepino[1,7-h][1,7]naphthyridin-8(9H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(6-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(methoxymethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(2-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclobutyl-1H-imidazol-1-yl)-9-(2-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(2,6-difluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(isoxazol-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(methoxymethyl)-1H-imidazol-1-yl)-9-(thiazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-ethyl-1H-1,2,4-triazol-1-yl)-9-(6-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(6-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(3-methylisothiazol-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(oxazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-ethynyl-1H-imidazol-1-yl)-9-(thiazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(2-fluoropyridin-3-yl)-2-(4-(oxazol-2-yl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-1-methyl-9-(3-methylisoxazol-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(2-methyloxazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(oxazol-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(6-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a][2,6]naphthyridin-5(4H)-one;   2-(4-ethyl-1H-imidazol-1-yl)-9-(tetrahydrofuran-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (R)-2-(4-ethyl-1H-imidazol-1-yl)-9-(tetrahydrofuran-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (S)-2-(4-ethyl-1H-imidazol-1-yl)-9-(tetrahydrofuran-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(tert-butyl)-1H-imidazol-1-yl)-9-(tetrahydrofuran-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (R)-2-(4-(tert-butyl)-1H-imidazol-1-yl)-9-(tetrahydrofuran-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (S)-2-(4-(tert-butyl)-1H-imidazol-1-yl)-9-(tetrahydrofuran-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-ethyl-1H-imidazol-1-yl)-9-(1-fluorocyclobutyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-ethyl-1H-imidazol-1-yl)-9-(3-fluorooxetan-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-ethyl-1H-imidazol-1-yl)-9-(1-hydroxyethyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (R)-2-(4-ethyl-1H-imidazol-1-yl)-9-(1-hydroxyethyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (S)-2-(4-ethyl-1H-imidazol-1-yl)-9-(1-hydroxyethyl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-acetyl-2-(4-methyl-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-acetyl-2-(4-cyclobutyl-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(1-methoxyethyl)-1H-imidazol-1-yl)-9-(prop-1-en-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (R)-2-(4-(1-methoxyethyl)-1H-imidazol-1-yl)-9-(prop-1-en-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (S)-2-(4-(1-methoxyethyl)-1H-imidazol-1-yl)-9-(prop-1-en-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(cyclopent-1-en-1-yl)-2-(4-(methoxymethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(methoxymethyl)-1H-imidazol-1-yl)-9-(prop-1-en-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(1-methoxyethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (S)-9-cyclopropyl-2-(4-(1-methoxyethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (R)-9-cyclopropyl-2-(4-(1-methoxyethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclobutyl-1H-imidazol-1-yl)-9-propionyl-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one; and   9-(tert-butyl)-2-(4-(methoxymethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(3-fluoropyrazin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(3-fluoropyridin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(thiazol-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(2-methylthiazol-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(pyrazin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(thiazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(2-methoxyethyl)-1H-imidazol-1-yl)-9-(thiazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(ethoxymethyl)-1H-imidazol-1-yl)-9-(4-methylthiazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-(ethoxymethyl)-1H-imidazol-1-yl)-9-(thiazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(4-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-10-fluoro-2-(4-(methoxymethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-methyl-1H-imidazol-1-yl)-9-(2-methyloxazol-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(3-(trifluoromethyl)-1H-pyrazol-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(6-hydroxypyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(6-methoxypyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(1H-pyrazol-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(2-fluoropyrimidin-5-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(2-fluoropyridin-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-cyclobutyl-1H-1,2,4-triazol-1-yl)-9-(6-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-12-fluoro-2-(4-(methoxymethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (R)-9-cyclopropyl-12-fluoro-2-(4-(1-methoxyethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-11-fluoro-2-(4-(methoxymethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(difluoromethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(fluoromethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   (R)-9-cyclopropyl-10-fluoro-2-(4-(1-methoxyethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   10-fluoro-9-(6-fluoropyridin-3-yl)-2-(3-methyl-1H-1,2,4-triazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-10-fluoro-2-(3-(methoxymethyl)-1H-1,2,4-triazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-10-fluoro-9-(2-fluoropyridin-3-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   10-fluoro-9-(2-fluoropyridin-3-yl)-2-(3-methyl-1H-1,2,4-triazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   10-fluoro-9-(2-fluoropyridin-3-yl)-2-(4-methyl-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(6-fluoropyridin-3-yl)-2-(4-(1-methoxycyclopropyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-methyl-1H-imidazol-1-yl)-9-(pyrazin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(6-fluoropyridin-3-yl)-2-(4-(3-hydroxyoxetan-3-yl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(2-methyloxazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclobutyl-1H-imidazol-1-yl)-9-(2-methyloxazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-methyl-1H-imidazol-1-yl)-9-(2-methyloxazol-4-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-cyclopropyl-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a][2,6]naphthyridin-5(4H)-one;   9-cyclopropyl-2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a][2,6]naphthyridin-5(4H)-one;   (R)-9-cyclopropyl-2-(4-(1-methoxyethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a][2,6]naphthyridin-5(4H)-one;   9-cyclopropyl-2-(4-(difluoromethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a][2,6]naphthyridin-5(4H)-one;   9-cyclopropyl-2-(4-(oxazol-5-yl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(isoxazol-5-yl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-methoxy-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(pyridin-4-yl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-((trifluoromethoxy)methyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(1-hydroxycyclopropyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(2-hydroxyethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(1-hydroxyethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(cyclopropyl(hydroxy)methyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-((trifluoromethoxy)methyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   methyl 2-(4-cyclopropyl-1H-imidazol-1-yl)-5-oxo-4,5,7,8-tetrahydro-[1,4]diazepino[7,1-a]isoquinoline-9-carboxylate;   2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(5-fluoropyridin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(6-fluoropyridin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(4-fluoropyridin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(3-cyclopropyl-1H-1,2,4-triazol-1-yl)-9-(5-fluoropyrazin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-(5-fluoropyrazin-2-yl)-2-(3-methyl-1H-1,2,4-triazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(2H-1,2,3-triazol-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(5-fluoropyrazin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-cyclopropyl-2-(4-(1-fluorocyclopropyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a][2,6]naphthyridin-5(4H)-one;   2-(4-cyclopropyl-1H-imidazol-1-yl)-9-(6-fluoropyrazin-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   9-isopropoxy-2-(4-(methoxymethyl)-1H-imidazol-1-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one;   or salts of these compounds.   
     
     
         8 . A pharmaceutical composition comprising a therapeutically effective amount of a compound according to  claim 1  and one or more pharmaceutically acceptable carriers. 
     
     
         9 . A combination comprising a therapeutically effective amount of the compound according to  claim 1  and one or more therapeutically active agents. 
     
     
         10 . A method of inhibiting mGluR5 activity in a subject, wherein the method comprises administering to the subject a therapeutically effective amount of the compound according to  claim 1 . 
     
     
         11 . A method of treating a disorder or a disease in a subject mediated by mGluR5, wherein the method comprises administering to the subject a therapeutically effective amount of a compound according to  claim 1 . 
     
     
         12 . A compound according to  claim 1 , for use as a medicament. 
     
     
         13 . A compound of the formula III 
       
         
           
           
               
               
           
         
         or a salt thereof, wherein A, R 2 , m, R 3 , n and R 4  are as defined according to  claim 1 , and X A  is halogen; or 
         a compound of formula V 
       
       
         
           
           
               
               
           
         
         or a salt thereof, wherein A, R 2 , m, R 3 , n and R 4  are as defined according to  claim 1 , and X A  is halogen; or 
         a compound of formula VI 
       
       
         
           
           
               
               
           
         
         or a salt thereof, wherein A, R 2 , m, R 3 , n and R 4  are as defined according to  claim 1 , and X A  is halogen; or 
         a compound of formula VIII 
       
       
         
           
           
               
               
           
         
         or a salt thereof, wherein A, R 2 , m, R 3 , n and R 4  are as defined according to  claim 1 , and R 1  is C 1-6 alkyl; C 1-6 halogenalkyl; C 1-6 cyanoalkyl; C 1-6 carboxyalkyl; C 1-6 hydroxyalkyl; C 1-4 alkoxy-C 1-6 alkyl; C 1-4 alkoxy-C 1-4 alkoxy-C 1-6 alkyl; C 1-4 alkylcarbonyl-C 1-6 alkyl; C 1-4 alkoxycarbonyl-C 1-6 alkyl; C 1-4 alkylcarbonyloxy-C 1-6 alkyl; C 1-6 aminoalkyl; C 1-4 alkylamino-C 1-6 alkyl; di(C 1-4 alkyl)amino-C 1-6 alkyl; aminocarbonyl-C 1-6 alkyl; C 1-4 alkylaminocarbonyl-C 1-6 alkyl; di(C 1-4 alkyl)aminocarbonyl-C 1-6 alkyl; C 1-4 alkylcarbonylamino-C 1-6 alkyl; C 1-4 alkylaminosulfonyl-C 1-6 alkyl; di(C 1-4 alkyl)aminosulfonyl-C 1-6 alkyl; C 2-6 alkenyl; C 2-6 halogenalkenyl; C 2-6 alkinyl; C 2-6 halogenalkinyl; or a three- to seven-membered monocyclic ring system which may be aromatic, saturated or unsaturated non-aromatic and which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system is bound via a carbon atom, and wherein the ring system may in turn be substituted once or more than once by R 6 ; each R 6  independently is halogen, hydroxy, cyano, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4  alkoxy, or C 1-4 halogenalkoxy; or two R 6  at the same ring atom together are oxo; or 
         a compound of formula IX 
       
       
         
           
           
               
               
           
         
         or a salt thereof, wherein A, R 2 , m, R 3 , n and R 4  are as defined according to  claim 1 , and R 1  is C 1-6 alkyl; C 1-6 halogenalkyl; C 1-6 cyanoalkyl; C 1-6 carboxyalkyl; C 1-6 hydroxyalkyl; C 1-4 alkoxy-C 1-6 alkyl; C 1-4 alkoxy-C 1-4 alkoxy-C 1-6 alkyl; C 1-4 alkylcarbonyl-C 1-6 alkyl; C 1-4 alkoxycarbonyl-C 1-6  alkyl; C 1-4 alkylcarbonyloxy-C 1-6 alkyl; C 1-6 aminoalkyl; C 1-4 alkylamino-C 1-6 alkyl; di(C 1-4 alkyl)amino-C 1-6 alkyl; aminocarbonyl-C 1-6 alkyl; C 1-4 alkylaminocarbonyl-Cl 6 alkyl; di(C 1-4 alkyl)aminocarbonyl-C 1-6 alkyl; C 1-4 alkylcarbonylamino-C 1-6 alkyl; C 1-4 alkylaminosulfonyl-C 1-6  alkyl; di(C 1-4 alkyl)aminosulfonyl-C 1-6 alkyl; C 2-6 alkenyl; C 2-6 halogenalkenyl; C 2-6 alkinyl; C 2-6 halogenalkinyl; or a three- to seven-membered monocyclic ring system which may be aromatic, saturated or unsaturated non-aromatic and which may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, wherein the ring system is bound via a carbon atom, and wherein the ring system may in turn be substituted once or more than once by R 6 ; each R 6  independently is halogen, hydroxy, cyano, C 1-4 alkyl, C 1-4 halogenalkyl, C 1-4  alkoxy, or C 1-4 halogenalkoxy; or two R 6  at the same ring atom together are oxo.