US2017305840A1PendingUtilityA1

Substituted tetracycline compounds

48
Assignee: PARATEK PHARM INNCPriority: Jul 9, 2003Filed: Dec 9, 2016Published: Oct 26, 2017
Est. expiryJul 9, 2023(expired)· nominal 20-yr term from priority
Inventors:Mark L. NelsonKwasi OhemengPaul AbatoVictor AmooHaregewein AssefaJoel BerniacBeena BhatiaTodd BowserJackson ChenMark GrierLaura HoneymanMohamed Y. IsmailOak K. KimJude MathewsRachid Mechiche
A61P 31/12A61P 31/00A61P 31/04A61P 29/00A61P 35/00A61P 33/06A61P 33/00C07C 237/48C07C 2601/14C07C 271/22C07C 275/30C07C 2601/16A61K 31/65C07C 271/54C07C 2601/02C07C 2603/46C07C 275/28A61P 19/00C07C 237/26A61P 19/08A61P 11/00Y02A50/30
48
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Claims

Abstract

The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.

Claims

exact text as granted — not AI-modified
1 - 49 . (canceled) 
     
     
         50 . A method for ameliorating a tetracycline responsive state in a subject in need thereof, the method comprising administering to said subject a tetracycline compound of the following structural formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, such that said tetracycline responsive state in said subject is ameliorated. 
       
     
     
         51 . The method of  claim 50 , wherein said tetracycline responsive state is an inflammatory disorder. 
     
     
         52 . The method of  claim 51 , wherein said tetracycline responsive state is an inflammatory condition of the skin. 
     
     
         53 . The method of  claim 51 , wherein said tetracycline responsive state is an inflammatory disorder caused by trauma. 
     
     
         54 . The method of  claim 51 , wherein said tetracycline responsive state is an inflammatory disorder caused by radiation. 
     
     
         55 . The method of  claim 50 , wherein said subject is a human. 
     
     
         56 . A method for ameliorating a tetracycline responsive state in a subject in need thereof, the method comprising administering to said subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a tetracycline compound of the following structural formula: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof, such that said tetracycline responsive state in said subject is ameliorated. 
       
     
     
         57 . The method of  claim 56 , wherein said tetracycline responsive state is an inflammatory disorder. 
     
     
         58 . The method of  claim 57 , wherein said tetracycline responsive state is an inflammatory condition of the skin. 
     
     
         59 . The method of  claim 57 , wherein said tetracycline responsive state is an inflammatory disorder caused by trauma. 
     
     
         60 . The method of  claim 57 , wherein said tetracycline responsive state is an inflammatory disorder caused by radiation. 
     
     
         61 . The method of  claim 56 , wherein said subject is a human.

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