Methods and compounds for treating proliferative disorders and viral infections

Abstract

The invention generally relates to methods and compounds for treating proliferative disorders, viral infections, or both. In some embodiments, the invention provides an anticancer or antiviral compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating a proliferative disorder or a viral infection including administering an anticancer or antiviral compound that binds to a thromboxane receptor, has preferential binding for either TPalpha (TPα) or TPbeta (TPβ) receptor subtype.

1 - 46 . (canceled) 
     
     
         47 . A method of treating a viral infection or inflammatory condition, the method comprising administering a compound of formula (CXII): 
       
         
           
           
               
               
           
         
       
       wherein:
 R 14  is selected from the group consisting of: an alkyl group, a branched alkyl group, and a cycloalkyl group; 
 R 15  is selected from the group consisting of 
 
       
         
           
           
               
               
           
         
       
       with R 3  selected from the list consisting of OH, and I; and
 R 16  is selected from the group consisting of —NO 2  and —CN, or a pharmaceutically acceptable salt thereof. 
 
     
     
         48 . The method of  claim 47 , wherein the compound is of formula (CXIII): 
       
         
           
           
               
               
           
         
       
     
     
         49 . The method of  claim 48 , wherein R 15  is selected from the group consisting of 
       
         
           
           
               
               
           
         
       
     
     
         50 . The method of  claim 49 , wherein:
 R 14  is selected from the group consisting of: an alkyl group and a branched alkyl group; and   R 15  is selected from the group consisting of   
       
         
           
           
               
               
           
         
       
     
     
         51 . The method of  claim 50 , wherein R 16  is —NO 2 . 
     
     
         52 . The method of  claim 51 , wherein R 14  is a branched alkyl group. 
     
     
         53 . The method of  claim 52 , wherein:
 R 14  is tent-butyl; and   R 15  is selected from the group consisting of   
       
         
           
           
               
               
           
         
       
     
     
         54 . The method of  claim 53 , wherein R 15  is 
       
         
           
           
               
               
           
         
       
     
     
         55 . The method of  claim 48 , wherein:
 R 14  is selected from the group consisting of an alkyl group and a branched alkyl group;   R 15  is selected from the group consisting of   
       
         
           
           
               
               
           
         
       
       and
 R 16  is —CN. 
 
     
     
         56 . The method of  claim 55 , wherein:
 R 14  is a branched alkyl group;   R 15  is selected from the group consisting of   
       
         
           
           
               
               
           
         
       
       and
 R 16  is —CN. 
 
     
     
         57 . The method of  claim 56 , wherein:
 R 14  is tent-butyl; and   R 15  is   
       
         
           
           
               
               
           
         
       
     
     
         58 . A method of treating a viral infection or inflammatory condition, the method comprising administering a compound of formula selected from the group consisting of (LVII), (LVIII), (LIX), and (LX): 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         59 . The method of  claim 47 , wherein the inflammatory condition is pneumonia.