Antimicrobial peptide stimulating sanitizing composition

Abstract

A method of increasing antimicrobial peptide concentration on the skin is provided. The method includes cleaning skin with at least one of a cleanser and a sanitizer and applying a topical composition to the skin. The topical composition is comprised of one or more polypeptides and natural extracts that increase the concentration of antimicrobial peptides.

What is claimed is: 
     
         1 . A topical sanitizing composition for stimulating the production of antimicrobial peptides, said composition comprising;
 about 0.02 wt. % to about 10.0 wt.% of an active ingredient;   at least about 40 wt. % of one or more C 1-6  alcohols; and water, wherein said active ingredient comprises one or more of a natural extract and a polypeptide, where said topical composition increases the concentration of antimicrobial peptides, as compared to an otherwise identical topical composition without the active ingredient.   
     
     
         2 . The topical sanitizing composition of  claim 1 , wherein said natural extract is one or more of a plant extract, a seed extract and a fruit extract. 
     
     
         3 . The topical sanitizing composition of  claim 1 , wherein said natural extract is a seed extract. 
     
     
         4 . The topical sanitizing composition of  claim 3 , wherein said seed extract is at least one of linseed extract, flaxseed extract, hemp seed extract, grape seed extract, and grapefruit seed extract. 
     
     
         5 . The topical sanitizing composition of  claim 4 , wherein said seed extract is a linseed extract. 
     
     
         6 . The topical sanitizing composition of  claim 1 , wherein said active ingredient is a polypeptide. 
     
     
         7 . The topical sanitizing composition of  claim 6 , wherein said polypeptide is at least one of an oligopeptide and a hexapeptide. 
     
     
         8 . The topical sanitizing composition of  claim 1 , wherein said topical sanitizing composition comprises about 0.05 to about 5.0 wt. % active ingredient, based on the weight of the total composition. 
     
     
         9 . The topical sanitizing composition of  claim 1 , wherein said topical sanitizing composition comprises about 0.1 to about 1.0 wt. % active ingredient, based on the weight of the total composition. 
     
     
         10 . The topical sanitizing composition of  claim 1 , wherein said C 1-6  alcohol is one or more of methanol, ethanol, propanol, butanol, pentanol, hexanol, and isomers and mixtures thereof. 
     
     
         11 . The topical sanitizing composition of  claim 1 , where said C 1-6  alcohol is present in an amount above about 70 wt. %, based on the weight of the total composition. 
     
     
         12 . The topical sanitizing composition of  claim 1 , wherein said topical composition comprises one or more humectants, selected from the group consisting of propylene glycol, hexylene glycol, 1,4-dihydroxyhexane, 1,2,6-hexanetriol, sorbitol, butylene glycol, caprylyl glycol, propanediols, such as methyl propane diol, dipropylene glycol, triethylene glycol, glycerin (glycerol), polyethylene glycols, ethoxydiglycol, polyethylene sorbitol, and combinations thereof. 
     
     
         13 . The topical sanitizing composition of  claim 12 , wherein said humectant comprises one or more of caprylyl glycol and glycerin. 
     
     
         14 . The topical sanitizing composition of  claim 12 , wherein said humectant is present in an amount up to about 20.0 wt. %, based on the weight of the total composition. 
     
     
         15 . The topical sanitizing composition of  claim 1 , wherein said topical composition comprises one or more moisturizing esters, selected from the group consisting of cetyl myristate, cetyl myristoleate, and other cetyl esters, diisopropyl sebacate, isopropyl myristate, and combinations thereof. 
     
     
         16 . The topical sanitizing composition of  claim 15 , wherein said moisturizing ester is present in an amount up to about 10.0 wt. %, based on the weight of the total composition. 
     
     
         17 . The topical sanitizing composition of  claim 1 , wherein said topical composition increases antimicrobial peptide concentration by a statistically significant amount, as compared to an otherwise identical composition without the active ingredient. 
     
     
         18 . The topical sanitizing composition of  claim 1 , wherein said topical composition increases the concentration of HBD-1 by at least about 20%, relative to an otherwise identical topical composition without said active ingredient. 
     
     
         19 . The topical sanitizing composition of  claim 1 , wherein said topical composition increases the concentration of HBD-2 by at least about 7%, relative to an otherwise identical topical composition without said active ingredient. 
     
     
         20 . The topical sanitizing composition of  claim 1 , wherein said topical composition increases the concentration of HBD-3 by at least about 18%, relative to an otherwise identical topical composition without said active ingredient. 
     
     
         21 . The topical sanitizing composition of  claim 1 , wherein said topical composition increases the concentration of LL-37 by at least about 32%, relative to an otherwise identical topical composition without said active ingredient. 
     
     
         22 . The topical sanitizing composition of  claim 1 , wherein said topical composition decreases the concentration of IL-8 by at least about 30%, relative to an otherwise identical topical composition without said active ingredient. 
     
     
         23 . The topical sanitizing composition of  claim 1 , wherein said topical composition increases the concentration of HBD-1 by at least about 4 pg/mL, relative to an otherwise identical topical composition without said active ingredient. 
     
     
         24 . The topical sanitizing composition of  claim 1 , wherein said topical composition increases the concentration of HBD-2 by at least about 4 pg/mL, relative to an otherwise identical topical composition without said active ingredient. 
     
     
         25 . The topical sanitizing composition of  claim 1 , wherein said topical composition increases the concentration of HBD-3 by at least about 1 pg/mL, relative to an otherwise identical topical composition without said active ingredient. 
     
     
         26 . A method of skin treatment to increase the production of antimicrobial peptides on the skin, said method comprising:
 applying a topical sanitizing composition to a skin surface, wherein said topical composition comprises:
 about 0.02 wt. % to about 10.0 wt. % of an active ingredient; 
 at least about 40 wt. % of one or more C 1-6  alcohols; and 
 the balance up to 100 wt. % being water, wherein said active ingredient comprises one or more of a natural extract and a polypeptide, where said topical composition increases the concentration of antimicrobial peptides on skin, as compared to an otherwise identical topical sanitizing composition without the active ingredient. 
   
     
     
         27 . A skin treatment composition comprising;
 about 0.02 wt. % to about 10.0 wt. % of an active ingredient comprising one or more of a natural extract and a polypeptide;   about 40.0 wt. % to about 95.0 wt.% of one or more C 1-6  alcohols;   about 0.01 wt. % to about 10.0 wt.% of a humectant;   about 0.01 wt. % to about 5.0 wt. % of a moisturizing ester; and   the balance up to 100 wt. % being water.   
     
     
         28 . A topical composition for increasing the innate immunity of the skin comprising;
 about 0.02 wt. % to about 10.0 wt. % of an active ingredient comprising one or more of a natural extract and a polypeptide;   about 40.0 wt. % to about 95.0 wt. % of one or more C 1-6  alcohols;   about 0.01 wt. % to about 5.0 wt. % of an emollient;   about 0.01 wt. % to about 5.0 wt. % of a viscosity modifier; and   water.   
     
     
         29 . A topical composition for increasing the innate immunity of the skin comprising;
 about 0.02 wt. % to about 10.0 wt. % of an active ingredient comprising one or more of a natural extract and a polypeptide;   about 40.0 wt. % to about 95.0 wt. % of one or more C 1-6  alcohols;   about 0.01 wt. % to about 5.0 wt. % of a foaming agent;   about 0.01 wt. % to about 10.0 wt. % of a humectant; and   water.