Mineral based compositions and use thereof

Abstract

Mineral-based composition and methods of use thereof in preventing skin damages, such as in subjects exposed to radiation, are provided.

1 . A hypotonic composition having a pH of less than 7, the composition comprises:
 (i) an allantoin;   (ii) selenium (Se) and zinc (Zn); and   (iii) a carrier.   
     
     
         2 . The composition of  claim 1 , further comprising a plurality of minerals comprising potassium (K), calcium (Ca), magnesium (Mg), sulfate (SO4), bromide (Br), manganese (Mn), copper (Cu), sulfur (S), tellurium (Te), iron (Fe), sodium (Na) of less than 1000 mg/l and chloride of less than 500 mg/l, silica (SiO2) and bicarbonate. 
     
     
         3 . The composition of  claim 1 , wherein said selenium (Se) has a concentration of 40-1000 mg/l, and said zinc (Zn) has a concentration of 4-1000 mg/l. 
     
     
         4 . The composition of  claim 1 , comprising said allantoin in an amount of 0.1-5% by weight. 
     
     
         5 . The composition of  claim 2 , comprising said plurality of minerals in an amount of 0.001-5% by weight. 
     
     
         6 . The composition of  claim 1  having a pH in the range of 5-7. 
     
     
         7 . The composition of  claim 2 , wherein the sodium levels are less than 500 mg/l. 
     
     
         8 . The composition of  claim 2 , wherein the chloride levels are less than 150 mg/l. 
     
     
         9 . The composition of  claim 2 , wherein said plurality of minerals consists of 50-500 mg/l of sodium, 25000-40000 mg/l potassium, 5000-120000 mg/l calcium, 20000-30000 mg/l magnesium, 50-150 mg/l chloride, 2000-2500 mg/l sulfate, 85-100 mg/l bromide, 5-70 mg/l manganese, 10-50 mg/l copper, 3-80 mg/l sulfur, 5-50 mg/l silica, 10-800 mg/l bicarbonate and 0.05-0.5 mg/l tellurium. 
     
     
         10 . The composition according to  claim 1 , wherein the carrier is selected from the group consisting of jojoba oil, coconut oil, aloe vera gel, cocoa butter, lecithin, almond oil, borage oil, canola oil, grape seed oil, olive oil, soybean oil, sunflower oil, wheat germ oil, apricot kernel oil, carrot oil, mango butter, evening primrose oil, black currant oil, avocado oil, macrocrystalline wax, paraffin, petrolatum, ozokerite, montan wax, beeswax, lanolin or a derivative, candelilla wax, ouricury wax, carnauba wax, Japan wax, cocoa butter, sugarcane wax, cork fiber wax, and mixtures thereof. 
     
     
         11 . The composition according to  claim 1 , wherein the carrier is selected from jojoba oil, coconut oil, aloe vera gel, and mixtures thereof. 
     
     
         12 . The composition of  claim 1 , further comprising a compound selected from the group consisting of vitamin E, vitamin A, benzoic acid, benzyl alcohol, cetyl alcohol, citric acid, glycerin, imidazolidinyl urea, isopropyl myristate, methylisothiazolinone, shea butter, sorbitan tristearate and derivatives or combinations thereof. 
     
     
         13 . The composition of  claim 1 , wherein the composition is in the form of a cream, an ointment, a gel, lotion, liniment, paste or an emulsion. 
     
     
         14 . The composition of  claim 1 , formulated as a topical composition. 
     
     
         15 . The composition of  claim 1 , for preventing or reducing damage to skin of a subject undergoing radiotherapy or laser treatment. 
     
     
         16 . The composition of  claim 1 , for preventing or reducing skin cancer occurrence or reoccurrence. 
     
     
         17 . A method of preventing or reducing skin damage in a subject in need thereof, the method comprises:
 topically applying to the skin of the subject an effective amount of a hypotonic composition having a pH of less than 7 and comprising:   (i) an allantoin;   (ii) selenium (Se) and zinc (Zn); and   (iii) a carrier.   
     
     
         18 . The method of  claim 17 , wherein said skin damage is caused by exposure to radiation or laser. 
     
     
         19 . The method of  claim 17 , wherein said subject is undergoing radiotherapy. 
     
     
         20 . The method of  claim 19 , wherein said radiotherapy is external-beam radiation therapy. 
     
     
         21 . The method of  claim 17 , for preventing skin cancer occurrence or reoccurrence. 
     
     
         22 . The method of  claim 17 , wherein said composition is adsorbed to the skin of the subject prior to said radiotherapy. 
     
     
         23 . A process for preparing a topical formulation comprising the steps of:
 (i) providing a mineral-based compositions comprising selenium (Se) and zinc (Zn);   (ii) mixing said mineral-based composition with a carrier at a temperature less than 10° C.; and   (iii) mixing the composition of step (ii) with at least one additional ingredient selected from vitamin E, vitamin A, aloe-vera leaf and allantoin at a temperature less than 10° C.   
     
     
         24 . The process of  claim 23  wherein said aloe-vera leaf and allantoin are mixed together at a temperature less than 10° C. prior to step (iii). 
     
     
         25 . The process of  claim 23 , wherein said temperature less than 10° C. is about 5° C. 
     
     
         26 . The process of  claim 23 , wherein said mixing is homogenizing. 
     
     
         27 . The process of  claim 23 , wherein said providing the mineral based composition comprises partially desalinating mineral water. 
     
     
         28 . The process of  claim 23 , wherein said formulation has a pH level in the range of 5-7. 
     
     
         29 . The process of  claim 28 , wherein said lowering pH level is by adding citric acid or a derivative thereof to the mineral-based composition of (i).