US2017275365A1PendingUtilityA1

Alpha-4-beta-7 heterodimer specific antagonist antibody

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Assignee: AMGEN INCPriority: Mar 20, 2009Filed: Nov 9, 2016Published: Sep 28, 2017
Est. expiryMar 20, 2029(~2.6 yrs left)· nominal 20-yr term from priority
Inventors:Hailing HsuIan FoltzFrederick W. JacobsenTaruna Arora-Khare
A61P 1/00C07K 16/28C07K 2317/32A61P 1/06C07K 2317/76A61P 1/18A61P 3/10C07K 2317/24A61P 1/04A61P 29/00C07K 2317/565A61P 5/48A61P 19/02C07K 2317/21A61P 1/16A61P 15/14C07K 16/2839A61P 37/06A61P 11/02A61P 11/06A61P 15/00C07K 2317/92A61P 11/00A61P 37/00C12N 15/11A61K 39/395
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Claims

Abstract

There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.

Claims

exact text as granted — not AI-modified
1 - 61 . (canceled) 
     
     
         62 . A method for the production of an antigen binding protein comprising culturing a host cell under conditions promoting expression and recovering the protein from the culture medium, wherein said host cell is transfected or transformed with a vector comprising a nucleic acid encoding the antigen binding protein, and wherein said antigen binding protein is selected from the group consisting of
 (a) an alpha4beta7 heterodimer specific antigen binding protein having a heavy chain variable region comprising CDR1, CDR2 and CDR3 from SEQ ID NO:37, and a light chain variable region comprising CDR1, CDR2 and CDR3 from SEQ ID NO:9; and   (b) the heterodimer specific antigen binding protein of (a), wherein the light chain variable region is at least 90% identical to SEQ ID NO:9, and the heavy chain variable region is at least 90% identical to SEQ ID NO:37.   
     
     
         63 . A method for the production of an antigen binding protein comprising culturing a host cell under conditions promoting expression and recovering the protein from the culture medium, wherein said host cell is transfected or transformed with a vector comprising a nucleic acid encoding the antigen binding protein, and wherein said antigen binding protein is selected from the group consisting of
 (a) an alpha4beta7 heterodimer specific antigen binding protein having a heavy chain variable region comprising CDR1, CDR2 and CDR3 from SEQ ID NO:52, and a light chain variable region comprising CDR1, CDR2 and CDR3 from SEQ ID NO:21; and   (b) the heterodimer specific antigen binding protein of (a), wherein the light chain variable region is at least 90% identical to SEQ ID NO:21, and the heavy chain variable region is at least 90% identical to SEQ ID NO:52.   
     
     
         64 . A method for the production of an antigen binding protein comprising culturing a host cell under conditions promoting expression and recovering the protein from the culture medium, wherein said host cell is transfected or transformed with a vector comprising a nucleic acid encoding the antigen binding protein, and wherein said antigen binding protein is selected from the group consisting of
 (a) an alpha4beta7 heterodimer specific antigen binding protein having a heavy chain variable region comprising CDR1, CDR2 and CDR3 from SEQ ID NO:32, and a light chain variable region comprising CDR1, CDR2 and CDR3 from SEQ ID NO:4; and   (b) the heterodimer specific antigen binding protein of (a), wherein the light chain variable region is at least 90% identical to SEQ ID NO:4, and the heavy chain variable region is at least 90% identical to SEQ ID NO:32.

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