US2017269100A1PendingUtilityA1

Assays for human nt-pro b-type natriuretic peptide, human pro b-type natriuretic peptide and human b-type natriuretic peptide

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Assignee: ABBOTT LABPriority: Nov 21, 2009Filed: Mar 30, 2017Published: Sep 21, 2017
Est. expiryNov 21, 2029(~3.3 yrs left)· nominal 20-yr term from priority
Inventors:John G. KonrathJeff A. Moore
G01N 2333/58G01N 33/6887G01N 33/74
61
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Claims

Abstract

The present disclosure relates to assays for detecting and/or quantifying the amount of human NT-pro B-type natriuretic peptide, human pro B-type natriuretic peptide and human B-type natriuretic peptide in a test sample.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . Immunodiagnostic reagents comprising:
 (a) a first capture antibody specific for human NT-pro B-type natriuretic peptide (”human NT-proBNP“);   (b) a second capture antibody which is specific to each of human pro B-type natriuretic peptide (”human proBNP“) and human brain natriuretic peptide (”hBNP“);   (c) a first detection antibody which is specific to each of human NT-proBNP and human proBNP; and   (d) a second detection antibody which is specific to hBNP.   
     
     
         2 . The immunodiagnostic reagents of  claim 1 , wherein the first capture antibody is antibody 15F11. 
     
     
         3 . The immunodiagnostic reagents of  claim 1 , wherein the second capture antibody is antibody 8.1. 
     
     
         4 . The immunodiagnostic reagents of  claim 1 , wherein the first detection antibody is antibody 15C4. 
     
     
         5 . The immunodiagnostic reagents of  claim 1 , wherein the second detection antibody is antibody 201.3. 
     
     
         6 . A kit for detecting the amount of human NT-pro B-type natriuretic peptide (”human NT-proBNP“), human pro B-type natriuretic peptide (”human proBNP“) and human brain natriuretic peptide (”hBNP“) in a test sample, said kit comprising:
 (a) instructions for conducting the assay of the test sample; and 
 (b) immunodiagnostic reagents comprising:
 (i) a first capture antibody specific for human NT-proBNP; 
 (ii) a second capture antibody which is specific to each of human proBNP and hBNP; 
 (iii) a first detection antibody which is specific to each of human NT-proBNP and human proBNP; and 
 (iv) a second detection antibody which is specific to hBNP. 
 
 
     
     
         7 . The kit of  claim 6 , wherein the first capture antibody is antibody 15F11. 
     
     
         8 . The kit of  claim 6 , wherein the second capture antibody is antibody 8.1. 
     
     
         9 . The kit of  claim 6 , wherein the first detection antibody is antibody 15C4. 
     
     
         10 . The kit of  claim 6 , wherein the second detection antibody is antibody 201.3.

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