US2017258821A1PendingUtilityA1
USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE
Est. expiryMay 30, 2034(~7.8 yrs left)· nominal 20-yr term from priority
Inventors:Melpo Christofidou-Solomidou
A61K 31/05A61K 31/7032A61K 31/09A61K 31/365
48
PatentIndex Score
0
Cited by
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References
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Claims
Abstract
The invention provides compositions and methods for radioprotection and chemoprevention using therapeutic and prophylactics methods of using (S,S)-SDG (R,R)-SDG, (S,R)-SDG (R,S)-SDG, SDG, SECO, EL, ED, analogs thereof, stereoisomers thereof and other related molecules.
Claims
exact text as granted — not AI-modified1 . A method for protecting a biomolecule, a cell, or a tissue from radiation damage in a subject in need thereof, the method comprising: administering to said subject an effective amount of at least one bioactive ingredient, wherein said bioactive ingredient comprises secoisolaricirecinol digluco side (SDG), secoisolariciresinol (SECO), enterodiol (ED), enterolactone (EL), analogs thereof, stereoisomers thereof, or a combination thereof.
2 . (canceled)
3 . (canceled)
4 . The method of claim 1 , wherein the subject has been or will be exposed to radiation as part of a therapeutic procedure or as part of a diagnostic procedure.
5 . The method of claim 4 , wherein the subject is a cancer patient who has or will receive radiotherapy.
6 . (canceled)
7 . (canceled)
8 . The method of claim 4 , wherein the diagnostic procedure is a dental or bone X-ray or a PET or CT scan.
9 . (canceled)
10 . The method of claim 1 , wherein the subject has been accidentally exposed to radiation.
11 . The method of claim 1 , wherein the subject has been or will be exposed to radiation as part of their occupation.
12 . (canceled)
13 . The method of claim 1 , wherein the subject has been exposed to radon or to radiation as a result of terrorism.
14 . (canceled)
15 . A method for protecting a biomolecule, a cell, or a tissue from carcinogen-induced damage, malignant transformation and cancer development in a subject in need thereof, the method comprising: administering to said subject an effective amount of at least one bioactive ingredient, wherein said bioactive ingredient comprises secoisolaricirecinol diglucoside (SDG), secoisolariciresinol (SECO), enterodiol (ED), enterolactone (EL), analogs thereof, stereoisomers thereof, or a combination thereof.
16 . (canceled)
17 . (canceled)
18 . The method of claim 15 , wherein the subject has cancer.
19 . (canceled)
20 . The method of claim 15 , wherein the subject has been or will be exposed to one or more carcinogens or chemical warfare toxicants accidentally or as a result of a terrorist act.
21 . The method of claim 15 , wherein the subject has been or will be exposed to one or more carcinogens as a result of a habit or their occupation.
22 . The method of claim 21 , wherein the habit is smoking.
23 . (canceled)
24 . The method of claim 21 , wherein the subject's occupation is as a laboratory technician.
25 . A method for protecting a biomolecule, a cell, or a tissue from damage by hypochlorite ions in a subject in need thereof, the method comprising: administering to said subject an effective amount of at least one bioactive ingredient, wherein said bioactive ingredient comprises secoisolaricirecinol diglucoside (SDG), secoisolariciresinol (SECO), enterodiol (ED), enterolactone (EL), analogs thereof, stereoisomers thereof, or a combination thereof.
26 . The method of claim 1 , wherein the biomolecule is a nucleic acid, a protein or a lipid.
27 . (canceled)
28 . The method of claim 1 , wherein the bioactive ingredient is (S,S)-SDG.
29 . The method of claim 1 , wherein the bioactive ingredient is (R,R)-SDG.
30 . The method of claim 1 , wherein the bioactive ingredient is synthetic SDG.
31 . (canceled)
32 . (canceled)
33 . (canceled)
34 . (canceled)
35 . (canceled)
36 . (canceled)
37 . A method for treating or preventing radiation damage, hypochlorite ion-induced damage, or carcinogen-induced damage, malignant transformation or cancer development in a subject who has been or will be exposed to radiation, to hypochlorite ions, or to one or more carcinogens, the method comprising: administering to said subject an effective amount of at least one bioactive ingredient, wherein said bioactive ingredient comprises secoisolaricirecinol diglucoside (SDG), secoisolariciresinol (SECO), enterodiol (ED), enterolactone (EL), analogs thereof, stereoisomers thereof, or a combination thereof.
38 . The method of claim 37 , wherein the subject has been or will be exposed to radiation as part of a therapeutic procedure or as part of a diagnostic procedure.
39 . The method of claim 38 , wherein the subject is a cancer patient who has or will receive radiotherapy.
40 . (canceled)
41 . (canceled)
42 . The method of claim 38 , wherein the diagnostic procedure is a dental or bone X-ray or a PET or CT scan.
43 . (canceled)
44 . The method of claim 37 , wherein the subject has been accidentally exposed to radiation or to the one or more carcinogens.
45 . The method of claim 37 , wherein the subject has been or will be exposed to radiation or to the one or more carcinogens as part of their occupation.
46 . The method of claim 45 , wherein the subject's occupation is as a laboratory technician.
47 . The method of claim 37 , wherein the subject has been exposed to radon.
48 . The method of claim 37 , wherein the subject has been exposed to radiation or to the one or more carcinogens as a result of terrorism.
49 . (canceled)
50 . The method of claim 37 , wherein the carcinogen-induced damage, malignant transformation or cancer development is cancer.
51 . The method of claim 50 , wherein the cancer is lung cancer or malignant mesothelioma.
52 . (canceled)
53 . (canceled)
54 . (canceled)
55 . (canceled)
56 . The method of claim 37 , wherein the subject has been or will be exposed to one or more carcinogens as a result of a habit.
57 . The method of claim 56 , wherein the habit is smoking.
58 . (canceled)
59 . (canceled)
60 . The method of claim 37 , wherein the one or more carcinogens is asbestos or tobacco smoke.
61 . (canceled)
62 . The method of claim 60 , wherein the subject is a smoker, a former smoker, or a non-smoker exposed to second hand smoke.
63 . (canceled)
64 . (canceled)
65 . (canceled)
66 . The method of claim 37 , wherein the bioactive ingredient is (S,S)-SDG.
67 . The method of claim 37 , wherein the bioactive ingredient is (R,R)-SDG.
68 . The method of claim 37 , wherein the bioactive ingredient is synthetic SDG.
69 . (canceled)
70 . (canceled)
71 . (canceled)
72 . The method of claim 37 , wherein the bioactive ingredient is SDG in a concentration about 25 μM to about 250 μM.
73 . (canceled)
74 . The method of claim 37 , wherein the subject is a human subject.
75 . A method for protecting a biomolecule, a cell, or a tissue from radiation damage or from carcinogen-induced damage or from damage by hypochlorite ions, the method comprising: contacting said biomolecule, cell, or tissue with an effective amount of at least one bioactive ingredient, wherein said bioactive ingredient comprises secoisolaricirecinol diglucoside (SDG), secoisolariciresinol (SECO), enterodiol (ED), enterolactone (EL), analogs thereof, stereoisomers thereof, or a combination thereof.
76 . (canceled)
77 . (canceled)
78 . (canceled)
79 . (canceled)
80 . The method of claim 75 , wherein the bioactive ingredient is (S,S)-SDG.
81 . The method of claim 75 , wherein the bioactive ingredient is (R,R)-SDG.
82 . The method of claim 75 , wherein the bioactive ingredient is synthetic SDG.
83 . (canceled)
84 . (canceled)
85 . (canceled)
86 . (canceled)
87 . (canceled)
88 . (canceled)
89 . (canceled)Join the waitlist — get patent alerts
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