Method of producing product inorganic compound and product inorganic compound

Abstract

A method of producing a product inorganic compound including: immersing a raw material inorganic compound having a volume of 10 −13 m 3 or more in an electrolyte aqueous solution or an electrolyte suspension; exchanging anions in the raw material inorganic compound with anions in the electrolyte aqueous solution or the electrolyte suspension; cations in the raw material inorganic compound are exchanged with cations in the electrolyte aqueous solution or the electrolyte suspension; or including a component (that excludes water, hydrogen, and oxygen) in the electrolyte aqueous solution or the electrolyte suspension not included in the raw material inorganic compound in the raw material inorganic compound; and obtaining a product inorganic compound having a volume of 10 −13 m 3 or more from the raw material inorganic compound.

1 . A method of producing a product inorganic compound comprising:
 (A) immersing a raw material inorganic compound having a volume of 10 −13  m 3  or more in an electrolyte aqueous solution or an electrolyte suspension;   (B1) exchanging anions in the raw material inorganic compound with anions in the electrolyte aqueous solution or the electrolyte suspension, and   (B2) cations in the raw material inorganic compound are exchanged with cations in the electrolyte aqueous solution or the electrolyte suspension; or   (B3) including a component (provided that it excludes water, hydrogen, and oxygen) in the electrolyte aqueous solution or the electrolyte suspension that is not included in the raw material inorganic compound in the raw material inorganic compound; and   (C) obtaining a product inorganic compound having a volume of 10 −13  m 3  or more from the raw material inorganic compound,   wherein the raw material inorganic compound has a solubility that is greater than 0 and 5 or less with respect to distilled water or the electrolyte aqueous solution at 20° C.,   solubility of the product inorganic compound in the electrolyte aqueous solution or the electrolyte suspension is larger than solubility of apatite in the electrolyte aqueous solution or the electrolyte suspension, and   wherein, in the electrolyte aqueous solution or the electrolyte suspension in which the raw material inorganic compound is immersed, elements other than hydrogen and oxygen, which are included in the product inorganic compound but not included in the raw material inorganic compound are included (provided that it excludes a production method in which an apatite without pores with a diameter of 20 μm or more and an aspect ratio of 2 or more is produced from at least one selected from the group consisting of calcium sulfate dihydrate, an α-type tricalcium phosphate, and calcium carbonate, a production method in which calcium sulfate is immersed in an ammonia or alkali metal hydroxide-containing aqueous solution, carbon dioxide is introduced into the aqueous solution, and calcium carbonate without pores with a diameter of 20 μm or more and an aspect ratio of 2 or more is produced, and a production method in which a product inorganic compound is calcium hydrogen phosphate without pores with a diameter of 20 μm or more and an aspect ratio of 2 or more).   
     
     
         2 . The method of producing a product inorganic compound according to  claim 1 ,
 wherein the product inorganic compound comprises a core portion and a surface layer portion, and solubility of the surface layer portion in the electrolyte aqueous solution or the electrolyte suspension is larger than solubility of the core portion in the electrolyte aqueous solution or the electrolyte suspension.   
     
     
         3 . The method of producing a product inorganic compound according to  claim 1 ,
 wherein the raw material inorganic compound is a porous body having a porosity of 30% or more.   
     
     
         4 . (canceled) 
     
     
         5 . The method of producing a product inorganic compound according to  claim 1 ,
 wherein, in the process C, a product inorganic compound which is a porous body including pores having an aspect ratio of at least 2 or more is obtained.   
     
     
         6 . (canceled) 
     
     
         7 . The method of producing a product inorganic compound according to  claim 1 ,
 wherein the raw material inorganic compound comprises an alkaline earth metal.   
     
     
         8 . (canceled) 
     
     
         9 . The method of producing a product inorganic compound according to  claim 1 ,
 wherein the raw material inorganic compound comprises calcium sulfate anhydrate.   
     
     
         10 . (canceled) 
     
     
         11 . (canceled) 
     
     
         12 . The method of producing a product inorganic compound according to  claim 1 ,
 wherein the electrolyte aqueous solution or the electrolyte suspension in which the raw material inorganic compound is immersed comprises at least one selected from the group consisting of an alkaline earth metal, an alkali metal, and an ammonia compound; or at least one selected from the group consisting, of: carbonate ions, bicarbonate ions, sulfate ions, hydrogen sulfate ions, hydrogen phosphate ions, hydroxide ions, and fluoride ions.   
     
     
         13 - 16 . (canceled) 
     
     
         17 . The method of producing a product inorganic compound according to  claim 1 ,
 wherein a temperature at which the raw material inorganic compound is immersed in the electrolyte aqueous solution or the electrolyte suspension is 10° C. or less.   
     
     
         18 - 20 . (canceled) 
     
     
         21 . The method of producing a product inorganic compound according to  claim 1 ,
 wherein the (A) comprises (a1) in which an ion component that is included in the raw material inorganic compound but not included in the product inorganic compound is removed from the electrolyte aqueous solution or the electrolyte suspension.   
     
     
         22 - 27 . (canceled) 
     
     
         28 . A product inorganic compound which is a product inorganic compound that has a volume of 10 −13  m 3  or more, comprising:
 a core portion, and a surface layer portion that covers the core portion and has an average conversion thickness of 1 μm or more,   wherein the core portion and the surface layer portion have different compositions,   wherein an inorganic compound of the surface layer portion comprises grain boundaries other than sinterable grain boundaries and preserves a form without disintegrating even if it is immersed in water for 24 hours, and   wherein an inorganic compound of the surface layer portion comprises at least one element included in a composition of the core portion (provided that it excludes a product inorganic compound that comprises a core portion formed of calcium carbonate that is not an artificial material and a surface layer portion formed of an apatite).   
     
     
         29 - 32 . (canceled) 
     
     
         33 . The product inorganic compound according to  claim 28 ,
 wherein a solubility of the inorganic compound of the surface layer portion with respect to distilled water at 20° C. is greater than a solubility of the inorganic compound of the core portion with respect to distilled water at 20° C.   
     
     
         34 . The product inorganic compound according to  claim 28 ,
 wherein a solubility of the inorganic compound of the surface layer portion with respect to distilled water at 20° C. is smaller than a solubility of the inorganic compound of the core portion with respect to distilled water at 20° C.   
     
     
         35 . The product inorganic compound according to  claim 28 ,
 wherein the inorganic compound of the surface layer portion comprises at least one selected from the group consisting of vaterite, aragonite, whitlockite, calcium hydrogen phosphate, calcium sulfate, calcium carbonate, and apatite.   
     
     
         36 . The product inorganic compound according to  claim 28 ,
 wherein the inorganic compound of the core portion comprises at least one selected from the group consisiting of calcium phosphate, calcium carbonate, calcium sulfate, an apatite, a calcium-containing glass, a coral, and a bone.   
     
     
         37 . (canceled) 
     
     
         38 . The product inorganic compound according to  claim 28 ,
 wherein a mass ratio between the core portion and the surface layer portion (core portion:surface layer portion) is 97:3 to 50:50.   
     
     
         39 - 46 . (canceled) 
     
     
         47 . A treatment method for reconstruction of a bone defect comprising the following (i) and (ii), or the following (iii):
 (i) filling a plurality of raw material inorganic compounds with a volume of 10 −13  m 3  or more in the bone defect,   (ii) applying an electrolyte aqueous solution to the raw material inorganic compound in the bone defect, thereby curing a curable composition comprising the raw material inorganic compounds and the electrolyte aqueous solution;   (iii) filling a mixed product obtained by mixing a curable composition comprising the raw material inorganic compound and the electrolyte aqueous solution in the bone defect.   
     
     
         48 - 53 . (canceled) 
     
     
         54 . The product inorganic compound according to  claim 28 , wherein
 the core portion comprises calcium phosphate and/or calcium carbonate; and   the surface layer portion comprises an apatite.   
     
     
         55 . A material for medical use in reconstructing a hard tissue,
 comprising a core portion, and a surface layer portion that covers the core portion;   the core portion and the surface layer portion having different compositions;   the core portion having a calcium component other than calcium hydrogen phosphate; and   the surface layer portion having calcium hydrogen phosphate.   
     
     
         56 . A curable composition for forming a calcium hydrogen phosphate-containing porous body; the composition comprising granules of a calcium component (provided that it excludes calcium dihydrogen phosphate), and 70 mass % or more of the granules having a particle diameter of 100 μm or more and 10 mm or less. 
     
     
         57 . The treatment method for reconstruction of a bone defect according to  claim 47 , wherein the curable composition is at least one selected from the group consisting of: carbonate apatite, vaterite-containing calcium carbonate, aragonite-containing calcium carbonate, calcium hydroxide, calcium fluoride, magnesium hydroxide, and whitlockite, provided that the product inorganic compound excludes an apatite without pores of 20 μm or more in diameter and an aspect ratio of 2 or more).