Systems and methods for enhancing platelet biogenesis and extending platelet lifespan with low level light

Abstract

The present disclosure is directed to systems and methods that can apply low level light (LLL) to facilitate platelet biogenesis or extend platelet lifespan. While not wishing to be bound by theory, it is believed that LLL can enhance the ATP synthesis by the mitochondria within platelets and/or platelet precursor cells, which, thereby, helps to enhance platelet biogenesis and extend the platelet lifespan. In some instances, LLL can facilitate in vitro and/or in vivo platelet biogenesis. In other instances, LLL can extend platelet lifespan in circulation. In still other instances, LLL can be employed to prolong the shelf-life of stored platelets.

What is claimed is: 
     
         1 . A system comprising:
 a controller device, comprising a non-transitory memory and a processor, configured to generate a control signal comprising a parameter for a low level light (LLL) application; and   a LLL generator device configured to receive the control signal, generate the LLL based on the parameter, and apply the generated LLL to at least one of bone marrow and liver to facilitate generation of at least one of platelets and platelet precursors and comprising at least one of a monochromatic laser and a light emitting diode (LED) configured to generate the LLL comprising a wavelength from 600 nm to 1500 nm,   wherein the parameter comprises at least one of an on time, an off time, a light density, a power, a power density, and an output characteristic.   
     
     
         2 . The system of  claim 1 , wherein an LLL energy density at the at least one of bone marrow and liver is from 0.001 J/cm 2  to 30 J/cm 2 . 
     
     
         3 . The system of  claim 1 , wherein an LLL energy density at the at least one of bone marrow and liver is from 0.001 J/cm 2  to 20 J/cm 2 . 
     
     
         4 . The system of  claim 1 , wherein an LLL energy density at the at least one of bone marrow and liver is from 0.1 J/cm 2  to 0.5 J/cm 2 . 
     
     
         5 . The system of  claim 1 , wherein the LLL comprises a wavelength from 600 nm to 1100 nm. 
     
     
         6 . The system of  claim 1 , wherein the LLL comprises a wavelength from 900 nm to 1000 nm. 
     
     
         7 . The system of  claim 1 , wherein the LLL generator device is configured to apply the LLL to the at least one of the bone marrow and the liver in at least a portion of a patient's body. 
     
     
         8 . The system of  claim 1 , wherein the controller is coupled to a power source configured to supply power to at least one of the controller and the LLL generator. 
     
     
         9 . A device comprising:
 a controller, comprising a non-transitory memory and a processor, configured to generate a control signal comprising a parameter for the low level light (LLL) application; and   a LLL generator device configured to receive the control signal, generate the LLL based on the parameter, and apply the generated LLL to at least one of bone marrow, liver, and stored platelets or platelet precursors, wherein the LLL generator device comprises at least one of a monochromatic laser and a light emitting diode (LED) configured to generate the LLL,   wherein the parameter comprises at least one of an on time, an off time, a light density, a power, a power density, and an output characteristic.   
     
     
         10 . The device of  claim 9 , wherein the LLL comprises a wavelength from 600 nm to 1500 nm. 
     
     
         11 . The device of  claim 9 , wherein the LLL comprises a wavelength from 600 nm to 1100 nm. 
     
     
         12 . The device of  claim 9 , wherein the LLL comprises a wavelength from 900 nm to 1000 nm. 
     
     
         13 . The device of  claim 9 , wherein the parameter comprises a power comprising a value from 1 mW to 1000 mW. 
     
     
         14 . The device of  claim 9 , wherein the parameter comprises a power density comprising a value from 0.1 mW/cm 2  to 5 W/cm 2 . 
     
     
         15 . The device of  claim 9 , wherein the parameter comprises an output characteristic comprising at least one of a pulsed output comprising a frequency from 1 Hz to 500 Hz and an a continuous output. 
     
     
         16 . A method, comprising:
 receiving, at a low level light (LLL) generator device, a control signal from a controller device, wherein the control signal comprises a parameter for a LLL application;   obtaining, by the LLL generator device, the parameter from the control signal; and   applying, by the LLL generator device, LLL, comprising a wavelength from 600 nm to 1500 nm, to at least one of bone marrow and liver to facilitate generation of at least one of platelets and platelet precursors according to the parameter,   wherein the parameter comprises at least one of an on time, an off time, a light density, a power, a power density, and an output characteristic.   
     
     
         17 . The method of  claim 16 , wherein an LLL energy density at the at least one of bone marrow and liver is from 0.001 J/cm 2  to 30 J/cm 2 . 
     
     
         18 . The method of  claim 16 , wherein an LLL energy density at the at least one of bone marrow and liver is from 0.001 J/cm 2  to 20 J/cm 2 . 
     
     
         19 . The method of  claim 16 , wherein an LLL energy density at the at least one of bone marrow and liver is from 0.1 J/cm 2  to 0.5 J/cm 2 . 
     
     
         20 . The system of  claim 1 , wherein the LLL comprises a wavelength from 600 nm to 1100 nm.