Anti-blepharitis compositions and their use

Abstract

Compositions and methods for the prevention and treatment of blepharitis, where the compositions include verbascoside, oligopeptide-10, and sulfonated shale oil, and the preparation of such compositions.

What is claimed is: 
     
         1 . A composition comprising verbascoside and oligopeptide-10, wherein the verbascoside is present in the composition in a concentration of 1.0×10 −4  to 1.0 percent by weight and the oligopeptide-10 is present in the composition in a concentration of 5.0×10 −6  to 0.50 percent by weight. 
     
     
         2 . The composition of  claim 1 , further comprising sulfonated shale oil. 
     
     
         3 . The composition of  claim 2 , wherein verbascoside and shale oil are present in the composition in a ratio of one part verbascoside to two parts shale oil by weight. 
     
     
         4 . The composition of  claim 1 , wherein verbascoside and oligopeptide-10 are present in the composition in a ratio of 20 parts verbascoside to one part oligopeptide-10 by weight. 
     
     
         5 . The composition of  claim 1 , further comprising one or more additional active ingredients selected from neem oil, turmeric extract, willowbark extract,  Euphrasia officinalis  extract, black seed oil, and anise extract. 
     
     
         6 . The composition of  claim 1 , wherein verbascoside is present in the composition in a concentration of about 0.5 percent by weight and oligopeptide-10 is present in the composition in a concentration of about 0.025 percent by weight. 
     
     
         7 . The composition of  claim 1 , wherein the composition is a cosmetic composition, further comprising one or more cosmetically acceptable excipients. 
     
     
         8 . The composition of  claim 7 , wherein the one or more excipients are selected from the group consisting of: solvents, sequestrants, humectants, thickening agents, emulsifiers, emollients, adsorbing agents, preservatives, fragrances, antioxidants, pH modifiers, texturizing agents, and combinations thereof. 
     
     
         9 . The composition of  claim 7 , wherein the composition is an eye pencil, an eye shadow, an eye liner, a mascara, a cosmetic primer, or a cosmetic serum. 
     
     
         10 . The composition of  claim 1 , wherein the composition is a lotion, a cream, or a liquid. 
     
     
         11 . The composition of  claim 1 , wherein the composition is dispersed on or in an absorbant substrate. 
     
     
         12 . A composition for treating or preventing blepharitis, comprising:
 a precombined concentrated mixture of active ingredients including verbascoside and oligopeptide-10; and   at least one cosmetic excipient;   wherein the precombined concentrated mixture is present in the composition in a concentration of 0.0001% to 5% by weight; and   wherein the verbascoside is present in the composition in a concentration of 1.0×10 −4  to 1.0 percent by weight and the oligopeptide-10 is present in the composition in a concentration of 5.0×10 −6  to 0.50 percent by weight.   
     
     
         13 . The composition of  claim 12 , further comprising sulfonated shale oil. 
     
     
         14 . The composition of  claim 12 , further comprising one or more additional active ingredients selected from neem oil, turmeric extract, willowbark extract,  Euphrasia officinalis  extract, black seed oil, and anise extract. 
     
     
         15 . The composition of  claim 12 , wherein verbascoside is present in the composition in a concentration of about 0.5 percent by weight and oligopeptide-10 is present in the composition in a concentration of about 0.025 percent by weight. 
     
     
         16 . The composition of  claim 12 , wherein the composition is an eye pencil, an eye shadow, an eye liner, a mascara, a cosmetic primer, or a cosmetic serum. 
     
     
         17 . The composition of  claim 12 , wherein the composition is a lotion, a cream, or a liquid. 
     
     
         18 . An eye makeup formulation, comprising:
 a precombined concentrated mixture of active ingredients for treating or preventing blepharitis, including verbascoside and a bioactive peptide, collectively present in the formulation in a concentration of 0.0001% to 5% by weight;   a wax; and   a colorant;   wherein the verbascoside is present in the composition in a concentration of 1.0×10 −4  to 1.0 percent by weight and the bioactive peptide is present in the composition in a concentration of 5.0×10 −6  to 0.50 percent by weight.   
     
     
         19 . The formulation of  claim 18 , further comprising one or more additional active ingredients selected from neem oil, turmeric extract, willowbark extract,  Euphrasia officinalis  extract, black seed oil, and anise extract. 
     
     
         20 . The formulation of  claim 18 , wherein the bioactive peptide is oligopeptide-10.