Coatings containing multiple drugs

Abstract

A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.

What is claimed is: 
     
         1 . A pharmaceutical product comprising:
 a. a core, and   b. a coating deposited on said core, said coating comprising at least one polymer layer in dry powder form, and   c. at least one pharmaceutical layer comprising a pharmaceutical agent having a morphology that is crystalline or semi-crystalline.   
     
     
         2 . The pharmaceutical product of  claim 1 , wherein said at least one polymer comprises a bioabsorbable polymer. 
     
     
         3 . The pharmaceutical product of  claim 1 , wherein said at least one polymer layer comprises a sintered layer in which the morphology of said pharmaceutical agent in said coating has not been substantially modified. 
     
     
         4 . The pharmaceutical product of  claim 1 , wherein said polymer of said at least one polymer layer is selected from PLA, PLGA, PGA, and Poly(dioxanone). 
     
     
         5 . The pharmaceutical product of  claim 1 , wherein said coating comprises five or more layers, as follows:
 a first polymer layer;   a first pharmaceutical layer comprising said at least one pharmaceutical agent;   a second polymer layer;   a second pharmaceutical layer comprising a second pharmaceutical agent; and   a third polymer layer.   
     
     
         6 . The pharmaceutical product of  claim 1 , wherein said coating comprises four or more layers, as follows:
 a first polymer layer;   a first pharmaceutical layer comprising said at least one pharmaceutical agent;   a second polymer layer; and   a second pharmaceutical layer comprising a second pharmaceutical agent.   
     
     
         7 . The pharmaceutical product of  claim 1 , comprising four or more layers, as follows:
 the first pharmaceutical layer comprising a first pharmaceutical agent;   a first polymer layer;   a second pharmaceutical layer comprising a second pharmaceutical agent; and   a second polymer layer.   
     
     
         8 . The pharmaceutical product of  claim 1 , wherein said pharmaceutical layer and said at least one polymer layer comprise alternate layers of pharmaceutical agent, or pharmaceutical agent and polymer, and layers of polymer without pharmaceutical agents. 
     
     
         9 . A pharmaceutical product comprising:
 a coating composition comprising at least one polymer layer,   a pharmaceutical layer comprising at least one pharmaceutical agent, and   wherein said at least one polymer layer comprises a sintered layer in which the morphology of said pharmaceutical agent in said coating has not been substantially modified, and   said first pharmaceutical agent is crystalline or semi-crystalline.   
     
     
         10 . The pharmaceutical product of  claim 9 , wherein said at least one polymer layer comprises a bioabsorbable polymer. 
     
     
         11 . The pharmaceutical product of  claim 9 , wherein said polymer of said at least one polymer layer is selected from PLA, PLGA, PGA, and Poly(dioxanone). 
     
     
         12 . The pharmaceutical product of  claim 9 , comprising five or more layers, as follows:
 a first polymer layer;   a first pharmaceutical layer comprising said at least one pharmaceutical agent;   a second polymer layer;   a second pharmaceutical layer comprising a second pharmaceutical agent; and   a third polymer layer.   
     
     
         13 . The pharmaceutical product of  claim 9 , comprising four or more layers, as follows:
 a first polymer layer;   a first pharmaceutical layer comprising said at least one pharmaceutical agent;   a second polymer layer; and   a second pharmaceutical layer comprising a second pharmaceutical agent.   
     
     
         14 . The pharmaceutical product of  claim 9 , wherein said pharmaceutical layer and said at least one polymer layer comprise alternate layers of pharmaceutical agent, or pharmaceutical agent and polymer, and layers of polymer without pharmaceutical agent.