US2017226047A1PendingUtilityA1

Process for the purification of melphalan

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Assignee: FARMABIOS SPAPriority: May 31, 2013Filed: Apr 27, 2017Published: Aug 10, 2017
Est. expiryMay 31, 2033(~6.8 yrs left)· nominal 20-yr term from priority
Inventors:Claudio Gianluca PozzoliValentina CanevariMatteo Curti
C07C 229/42C07C 269/08C07C 227/20C07C 269/06C07C 229/36C07C 227/40
45
PatentIndex Score
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Claims

Abstract

A method for the purification and preparation of melphalan that allows to obtain melphalan with purity higher than 99.5% is described.

Claims

exact text as granted — not AI-modified
1 ) Melphalan and melphalan hydrochloride having HPLC purity of >99.5%. 
     
     
         2 ) Melphalan and melphalan hydrochloride according to  claim 1  wherein impurity G is NMT 0.5%. 
     
     
         3 ) Melphalan and melphalan hydrochloride according to  claim 1  having HPLC purity of >99.8%. 
     
     
         4 ) Melphalan and melphalan hydrochloride according to  claim 1  wherein impurity G is NMT 0.2%. 
     
     
         5 ) Melphalan and melphalan hydrochloride according to  claim 1  wherein impurity G is NMT 0.1%.

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