Wound healing compositions involving medicinal honey, mineral ions and methylglyoxal, and methods of use

Abstract

The invention provides compositions based on either medicinal honey containing broad spectrum antibacterial activities of peroxide, polyphenols and methylglyoxal, or an effective amount of an active anti-inflammatory ingredient of mineral solids fortified with methylglyoxal antibacterial activity, or a mixture of both for the treatment of wounds; and methods of treating a wound, comprising contacting a wound with any one of the above compositions or a wound dressing containing any one of the above compositions.

1 . A wound healing composition, comprising:
 a medicinal honey; and   a concentration of methylglyoxal being added to said medicinal honey effective to reduce a number of viable microorganisms at a wound site.   
     
     
         2 . The wound healing composition of  claim 1 , wherein the medicinal honey naturally contains or generates 2-4 mM hydrogen peroxide upon dilution with an aqueous medium. 
     
     
         3 . The wound healing composition of  claim 1 , wherein the medicinal honey naturally contains a polyphenol concentration ranging between 275 and 575 gallic acid equivalents per gram of the medicinal honey. 
     
     
         4 . The composition of  claim 1 , wherein the medicinal honey is buckwheat honey. 
     
     
         5 . The composition of  claim 1 , wherein said concentration of methylglyoxal ranges from 500 to 2000 mg per kg. 
     
     
         6 . The wound healing composition of  claim 1 , wherein the wound healing composition is replaced on a wound at least once. 
     
     
         7 . A wound healing composition, comprising:
 a pharmaceutically acceptable carrier;   an effective amount of an active ingredient of mineral solids, said mineral solids including at least one of a magnesium salt, a potassium salt, a calcium salt, a zinc salt, a rubidium salt, a bromide salt, and a sulfate salt; and   a concentration of methylglyoxal effective to reduce a number of microorganisms at a wound site being added to said active ingredient.   
     
     
         8 . The wound healing composition of  claim 7 , wherein each of the salts includes a pharmaceutically-acceptable counterion. 
     
     
         9 . The wound healing composition of  claim 7 , wherein the active ingredient of mineral solids includes 1.5-75 parts of magnesium ions, 0.5-75 parts of potassium ions, 0.001-10 parts of calcium ions, 0.0001-10 parts of zinc ions, up to 5 parts of rubidium ions, 0.001-20 parts of bromide ions, and up to 20 parts of sulfate ions, said parts expressing a mass of a respective ions divided by a total mass of the mineral solids. 
     
     
         10 . The wound healing composition of  claim 7 , wherein said methylglyoxal added to said active ingredient ranges from 500 to 2000 mg/kg of the composition. 
     
     
         11 . The wound healing composition of  claim 7 , wherein the pharmaceutically-acceptable carrier includes at least one of water, polyethylene glycol, an ointment, and a cream base. 
     
     
         12 . The wound healing composition of  claim 7 , wherein a pH of the composition is between 3.0-7.0. 
     
     
         13 . The wound healing composition of  claim 7 , wherein the wound healing composition is replaced on a wound at least once. 
     
     
         14 . A wound healing composition, comprising:
 a first would healing composition, including:
 a medicinal honey; and 
 a concentration of methylglyoxal being added to said medicinal honey effective to reduce a number of viable microorganisms at a wound site; 
   a second wound healing composition, including:
 a pharmaceutically acceptable carrier; 
 an effective amount of an active ingredient of mineral solids, said mineral solids including at least one of a magnesium salt, a potassium salt, a calcium salt, a zinc salt, a rubidium salt, a bromide salt, and a sulfate salt; and 
 a concentration of methylglyoxal effective to reduce a number of microorganisms at a wound site being added to said active ingredient; and 
 a ratio of a volume of said first wound healing composition to a volume of said second wound healing composition being between 1:9 and 9:1. 
   
     
     
         15 . A wound healing dressing, comprising:
 the wound healing composition according to  claim 1 ; and   a support.   
     
     
         16 . A wound healing dressing, comprising:
 the wound healing composition according to  claim 7 ; and   a support.   
     
     
         17 . A wound healing dressing, comprising:
 the wound healing composition according to  claim 14 ; and   a support.   
     
     
         18 . The wound healing dressing of  claim 15 , wherein the support includes at least one of a fibrous gauze material, a hydrogel, a foam, a film, a hydrocolloid, a collagen, and an alginate. 
     
     
         19 . A method of treating a wound, which comprises contacting a wound with the composition of  claim 1 . 
     
     
         20 . A method of treating a wound, which comprises contacting a wound with the wound dressing of  claim 15 . 
     
     
         21 . The wound healing composition of  claim 14 , wherein the wound healing composition is replaced on a wound at least once.