Patient-and Condition-Specific Platelet Transfusion Support

Abstract

Determining and implementing individualized platelet support regimens (e.g., administering specified platelet numbers; and, schedules for administration or other intervention, in accordance with the requirements assessed for individual patients) by: monitoring platelet clearance kinetics; analyzing the kinetics to determine value(s) proportionally representing both the extent and frequency of vascular injury, and using such value(s) to determine the momentary requirement for maintaining vascular integrity, and constructing a corresponding platelet administration regimen where said regimen preferably provides for the utilization of platelets selected, from a platelet inventory, in accordance with the recipient's molecular “type”. Releasing from an inventory of a platelet inventory system the particular typed or profiled platelet amounts required to satisfy the platelet administration regimen of each patient. Establishing a replenishing inventory of antigen-typed or antigen-profiled platelets or other cells, which are perishable and may be replaced after expiration, where the inventory can be virtual or held across several locations.

What is claimed is: 
     
         1 . A method for personalizing a platelet administration regimen for a patient with reduced platelet production, comprising:
 recording a platelet survival curve by determining concentration of platelets at a plurality of times following platelet transfusion;   analyzing the platelet survival curve to determine value(s) proportionally representing both the extent and frequency of vascular injury, expressed in terms of platelet quantities or platelet concentration required to repair said vascular injury;   using said value(s) to determine a platelet transfusion requirement for maintaining vascular integrity; and   administering not substantially less than the amount of platelets to satisfy said platelet transfusion requirement, to the patient.   
     
     
         2 . The method of  claim 1  wherein the times for determining platelet concentration span a 1-24 hour period. 
     
     
         3 . The method of  claim 1  wherein the concentration determined is of labeled or unlabeled platelets. 
     
     
         4 . The method of  claim 1  further including using said value(s) to determine a platelet transfusion prescription including the platelet quantity required for each of a plurality of transfusions performed at a plurality of times. 
     
     
         5 . The method of  claim 4  wherein the platelets are continuously transfused into the patient. 
     
     
         6 . The method of  claim 4  wherein the interval between transfusions and the quantity of platelets administered at each transfusion is re-determined so as to increase said interval. 
     
     
         7 . A tracking method for preserving inventory of platelets having a particular antigen type or antigen profile, comprising:
 determining virtual or actual inventory quantity of platelets having a particular antigen type or profile;   determining quantity of platelets having a particular antigen type or profile to be given a particular patient, by:   recording a platelet survival curve for said patient by determining concentration of platelets at a plurality of times following platelet transfusion;   analyzing the platelet survival curve to determine value(s) proportionally representing both the extent and frequency of vascular injury, expressed in terms of platelet quantities or platelet concentration required to repair said vascular injury;   using said value(s) to determine a platelet transfusion requirement for maintaining vascular integrity; and   removing said platelet transfusion requirement from inventory.   
     
     
         8 . The method of  claim 7  further including replenishing said platelet transfusion requirement into inventory. 
     
     
         9 . The method of  claim 7  further including removing from inventory platelets which reach or have passed an expiration period. 
     
     
         10 . The method of  claim 9  further including replenishing said expired platelets into inventory. 
     
     
         11 . The method of  claim 7  further including administering not substantially more than the amount of platelets to satisfy said platelet transfusion requirement to the patient in accordance with said patient's molecular attribute profile and antibody status. 
     
     
         12 . The method of  claim 7  wherein removing platelets from inventory means not exclusively reserving the right to use them as against any other party holding or having rights to said removed platelets. 
     
     
         13 . The method of  claim 7  wherein replenishing platelets into inventory means exclusively reserving the right to use them as against any other party holding or having rights to said replenished platelets. 
     
     
         14 . The method of  claim 7  wherein the times for determining platelet concentration span a 24-48 hour period. 
     
     
         15 . The method of  claim 7  wherein the concentration determined is of labeled or unlabeled platelets. 
     
     
         16 . The method of  claim 7  further including using said value(s) to determine a platelet transfusion prescription including the platelet quantity required for each of a plurality of transfusions performed at a plurality of times. 
     
     
         17 . A method for personalizing a platelet administration regimen for a patient with reduced platelet production, comprising:
 recording a platelet survival curve by determining concentration of platelets at a plurality of times following platelet transfusion;   analyzing the platelet survival curve to determine value(s) proportionally representing both the extent and frequency of vascular injury, expressed in terms of platelet quantities or platelet concentration required to repair said vascular injury;   using said value(s) to determine a platelet transfusion requirement for maintaining vascular integrity; and   administering not substantially more than the amount of platelets to satisfy said platelet transfusion requirement, to the patient.   
     
     
         18 . The method of  claim 17  wherein the times for determining platelet concentration span a 1-24 hour period. 
     
     
         19 . The method of  claim 17  further including using said value(s) to determine a platelet transfusion prescription including the platelet quantity required for each of a plurality of transfusions performed at a plurality of times. 
     
     
         20 . The method of  claim 17  wherein the interval between transfusions and the quantity of platelets administered at each transfusion is re-determined so as to increase said interval.