Methods for Treating Viral Infections Using Hydrogen Sulfide Donors

Abstract

Certain embodiments are directed to methods of treating respiratory infection by administering an H 2 S donor.

1 . A method for treating an orthomyxovirus viral infection of the respiratory tract of a subject comprising administering an effective amount of a H 2 S donor to the subject. 
     
     
         2 . The method of  claim 1 , wherein the orthomxyovirus is Influenza A, Influenza B, or Influenza C virus. 
     
     
         3 . The method of  claim 1 , wherein the subject is suspected of having a respiratory tract infection. 
     
     
         4 . The method of  claim 1 , wherein the subject has been diagnosed with a respiratory tract infection. 
     
     
         5 . The method of  claim 1 , wherein the subject is suspected of being exposed to orthomyxovirus. 
     
     
         6 . The method of  claim 1 , wherein the H 2 S donor is administered by inhalation or inspiration into the respiratory tract. 
     
     
         7 . The method of  claim 1 , wherein the H 2 S donor is a slow release H 2 S donor. 
     
     
         8 . The method of  claim 1 , wherein the slow release H 2 S donor is administered in combination with a fast release H 2 S donor. 
     
     
         9 . The method of  claim 1 , wherein the H 2 S donor is Gyy4137, ACS67, diallyl trisulfide, NaHS, ATB-343, ATB-337, or AP67. 
     
     
         10 . The method of  claim 1 , wherein the H 2 S donor is Gyy4137 or AP67.