Oxazole compound and pharmaceutical composition

Abstract

The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein R 1 is an aryl group which may have one or more substituents; R 2 is an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by —Y 1 -A 1 - or —Y 2 —C(═O)— wherein Y 1 is a group such as —C(═O)—, A 1 is a group such as a lower alkylene group, and Y 2 is a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.

1 - 14 . (canceled) 
     
     
         15 . A method for obtaining cells expressing phosphodiesterase (PDE) 4, comprising:
 preparing a vector containing cDNA encoding human PDE4,   introducing the vector into mammalian cells,   cultivating the cells in a medium, and   collecting the cells   
     
     
         16 . The method of  claim 15 , wherein the cells are COS-7 cells. 
     
     
         17 . The method of  claim 15 , wherein the vector is a plasmid vector. 
     
     
         18 - 24 . (canceled)