Esterified Polysaccharide Osmotics

Abstract

Esterified polysaccharide osmotics are provided as are the use of same, a process for synthesis of same, and compositions containing same.

What is claimed is: 
     
         1 . A polysaccharide osmotic comprising monosaccharide monomers, which are esterified at least partially with maleic acid, wherein the monosaccharide monomers include glucose and/or fructose, and wherein the average molecular weight of the polysaccharide is between 15,000 and 25,000 g/mol. 
     
     
         2 . The polysaccharide osmotic according to  claim 1 , wherein the polysaccharide has a degree of polymerization between 10 and 170. 
     
     
         3 . The polysaccharide osmotic according to  claim 1 , wherein a 7.5 weight percent aqueous solution of the polysaccharide has an osmolarity greater than 11.9 mosm/L. 
     
     
         4 . The polysaccharide osmotic according to  claim 1 , wherein the polysaccharide has a degree of substitution between 0.01 and 3. 
     
     
         5 . A method for carrying out a dialysis treatment comprising dialyzing blood or a patient with a dialysis solution comprising the polysaccharide osmotic of  claim 1 . 
     
     
         6 . The method of  claim 5 , wherein the dialysis treatment comprises a hemodialysis treatment. 
     
     
         7 . The method of  claim 5 , wherein the dialysis treatment comprises a peritoneal dialysis treatment. 
     
     
         8 . A method for preparation of a polysaccharide osmotic, comprising the steps of:
 a. mixing a polysaccharide with a first organic solvent to form a dispersion or solution, and   b. mixing the dispersion or solution obtained in step a. with a maleic acid anhydride to form the esterified polysaccharide osmotic of  claim 1 .   
     
     
         9 . The method according to  claim 8 , comprising the additional step of:
 c. precipitating the esterified polysaccharide osmotic obtained in step b. by adding a second organic solvent, wherein the esterified polysaccharide osmotic has a greater solubility in the first organic solvent than in the second organic solvent or in a mixture of the first and second organic solvents.   
     
     
         10 . A dialysis solution comprising at least one polysaccharide osmotic according to  claim 1 , and water. 
     
     
         11 . A kit configured for the preparation of the dialysis solution according to  claim 10 , comprising:
 a first component,   a second component, and   optionally one or more additional components, wherein the dialysis solution is obtained by mixing the first component with the second component and optionally with the additional component(s).   
     
     
         12 . A solid composition suitable for preparation of the dialysis solution according to  claim 10 , wherein the dialysis solution is obtainable by dissolving the solid composition in a solvent. 
     
     
         13 . A method of preparing a dialysis solution, comprising mixing at least one polysaccharide osmotic according to  claim 1 , with water. 
     
     
         14 . A method of preparing a dialysis solution, comprising mixing together the first component, the second component, and the one or more additional components, of the kit of  claim 11 , wherein the kit includes the one or more additional components. 
     
     
         15 . A method of preparing a dialysis solution, comprising dissolving the solid composition of  claim 12  in a solvent, to form a solution, and mixing the solution with water.