Topical composition replacing water with hyaluronic acid as the primary ingredient

Abstract

A biologic formulation of 20% to 95% by weight of hyaluronic acid is provided such that the hyaluronic acid is the most common ingredient in the formulation. The formulation preferably also includes 0.1% to 1.5% by weight of a preservative, and a pH adjuster configured to provide a pH of less than 5.0 in the formulation. The hyaluronic acid is a combination of two or more different molecular weights of hyaluronic acid. The different molecular weights of hyaluronic acid are preferably cross-linked with glucosamine and ceramides.

1 . A biologic formulation in an aqueous solution, comprising:
 20% to 95% by weight of hyaluronic acid, said hyaluronic acid comprising the most common ingredient in the formulation wherein the hyaluronic acid comprises a combination of a first molecular weight hyaluronic acid, a second molecular weight hyaluronic acid, and a third molecular weight hyaluronic acid;   0. 1% to 1.5% by weight of preservative; and   a pH adjuster configured to provide a pH of less than 5.0 in the formulation.   
     
     
         2 . (canceled) 
     
     
         3 . The biologic formulation of  claim 1 , wherein the first molecular weight hyaluronic acid comprises hyaluronic acid having a molecular weight less than 1,500,000 Daltons, wherein the second molecular weight hyaluronic acid comprises hyaluronic acid having a molecular weight less than 100,000 Daltons, and wherein the third molecular weight hyaluronic acid comprises hyaluronic acid having a molecular weight less than 10,000 Daltons. 
     
     
         4 . The biologic formulation of  claim 3 , wherein the first molecular weight hyaluronic acid comprises hyaluronic acid having a molecular weight between 750,000 Daltons and 1,250,000 Daltons, wherein the second molecular weight hyaluronic acid comprises hyaluronic acid having a molecular weight between 50,000 Daltons and 75,000 Daltons, and wherein the third molecular weight hyaluronic acid comprises hyaluronic acid having a molecular weight between 3,000 Daltons and 8,000 Daltons. 
     
     
         5 . The biologic formulation of  claim 1 , wherein the hyaluronic acid comprises 30% to 90% of the first molecular weight hyaluronic acid, 5% to 20% of the second molecular weight hyaluronic acid, and 1% to 5% of the third molecular weight hyaluronic acid. 
     
     
         6 . The biologic formulation of  claim 1 , wherein the hyaluronic acid comprises 10% to 90% of the first molecular weight hyaluronic acid, 10% to 70% of the second molecular weight hyaluronic acid, and 1% to 35% of the third molecular weight hyaluronic acid. 
     
     
         7 . The biologic formulation of  claim 1 , wherein the first molecular weight, second molecular weight, and third molecular weight hyaluronic acid is cross-linked with glucosamine and ceramides. 
     
     
         8 . The biologic formulation of  claim 1 , further comprising a rheology modifier selected from the group consisting of carbomer, cellulose, and xantham gum, wherein the rheology modifier comprises 0.01% to 1% by weight of the formulation. 
     
     
         9 . (canceled) 
     
     
         10 . The biologic formulation of  claim 1 , further comprising:
 1% to 5% by weight of a non-soap based emulsifier; and   2% to 8% by weight of emollients;   wherein the non-soap based emulsifier comprises lecithin, and the emollients comprise a combination of caprylic/capric triglyceride, squalane, natural oils, and/or butters.   
     
     
         11 . (canceled) 
     
     
         12 . The biologic formulation of  claim 1 , further comprising 0.1% to 25% by weight of a physical exfoliator. 
     
     
         13 . The biologic formulation of  claim 1 , further comprising 0.5% to 2% by weight of allantoin and/or a monographed topical analgesic. 
     
     
         14 . (canceled) 
     
     
         15 . The biologic formulation of  claim 13 , wherein the topical analgesic comprises a strong ammonia solution. 
     
     
         16 . The biologic formulation of  claim 1 , wherein the preservative comprises a combination of sodium benzoate and potassium sorbate, wherein the pH adjuster comprises ascorbic acid. 
     
     
         17 . (canceled) 
     
     
         18 . The biologic formulation of  claim 1 , wherein the biologic formulation is an internal formulation comprising 60% to 95% by weight of hyaluronic acid, 0.1% of the preservative, and pH adjuster configured to lower the pH to less than 4.0. 
     
     
         19 . The biologic formulation of  claim 18 , further comprising 0.01% to 5% of botanical extracts, 2% to 10% of glycerin, and 0.01% to 5% phytoceramides. 
     
     
         20 . The biologic formulation of  claim 18 , further comprising 0.1% to 1.0% of melatonin. 
     
     
         21 . A biologic formulation, comprising:
 60% to 95% by weight of hyaluronic acid, said hyaluronic acid comprising the most common ingredient in the formulation;   0. 1% to 1.5% by weight of a preservative; and   a pH adjuster configured to provide a pH of less than 4.0 in the formulation.   
     
     
         22 . The biologic formulation of  claim 21 , further comprising 0.01% to 5% of botanical extracts, 2% to 10% of glycerin, 0.01% to 5% phytoceramides, and 0.1% to 1.0% of melatonin. 
     
     
         23 . The biologic formulation of  claim 21 , wherein the hyaluronic acid comprises a combination of a first molecular weight hyaluronic acid, a second molecular weight hyaluronic acid, and a third molecular weight hyaluronic acid, wherein the first molecular weight hyaluronic acid comprises hyaluronic acid having a molecular weight less than 1,500,000 Daltons, wherein the second molecular weight hyaluronic acid comprises hyaluronic acid having a molecular weight less than 100,000 Daltons, and wherein the third molecular weight hyaluronic acid comprises hyaluronic acid having a molecular weight less than 10,000 Daltons, and wherein the first molecular weight, second molecular weight, and third molecular weight hyaluronic acid is cross-linked with glucosamine and ceramides. 
     
     
         24 . The biologic formulation of  claim 21 , further comprising a rheology modifier selected from the group consisting of carbomer, cellulose, and xantham gum, wherein the rheology modifier comprises 0.01% to 1% by weight of the formulation. 
     
     
         25 . The biologic formulation of  claim 1 , further comprising:
 1% to 5% by weight of a non-soap based emulsifier; and   2% to 8% by weight of emollients.