US2017191079A1PendingUtilityA1
Method of increasing the function of an aav vector
Est. expiryApr 7, 2025(expired)· nominal 20-yr term from priority
A61P 43/00A61P 31/12A61P 37/00C12N 7/00C12N 2750/14152A61K 48/00C12N 2750/14122A61K 48/0091C12N 15/86C12N 2750/14142A61K 48/005C12N 2750/14143C07K 14/005
67
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Claims
Abstract
A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
Claims
exact text as granted — not AI-modified1 . A vector comprising an AAV capsid selected from the group consisting of: rh20, which has an amino acid sequence of SEQ ID NO:1 or a sequence having at least 97% identity thereto; rh32/33, which has an amino acid sequence of SEQ ID NO:2 or a sequence having at least 97% identity thereto; rh39, which has an amino acid sequence of SEQ ID NO:3 or a sequence having at least 97% identity thereto; rh46, which has an amino acid sequence of SEQ ID NO:4 or a sequence having at least 97% identity thereto; rh73, which has an amino acid sequence of SEQ ID NO:5 or a sequence having at least 97% identity thereto; rh74 which has an amino acid sequence of SEQ ID NO:6 or a sequence having at least 97% identity thereto.
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