Multicomponent oral care composition

Abstract

The present invention relates to a multicomponent oral health care composition, comprising a source of a fluoride ion, and a source of a calcium ion, a source of a phosphate ion, and stabilised chlorine dioxide, that can be used as a toothpaste, oral spray or a mouth wash/oral rinse formulation. The different components in the composition act synergistically together to clean the teeth and mucous membranes of an oral cavity of a subject, perfuming them or protecting them in order to keep them in good condition, change their appearance or correct unpleasant odours. They achieve this by inhibiting caries, promoting teeth remineralisation, and helping to alleviate dentine hypersensitivity, gingivitis and periodontal disease.

1 . An oral care composition comprising:
 i) A source of a fluoride ion;   ii) A source of a calcium ion;   iii) A source of a phosphate ion; and   iv) stabilised chlorine dioxide.   
     
     
         2 . An oral care composition according to  claim 1 , wherein the source of a calcium ion and the source of a phosphate ion is an apatite species. 
     
     
         3 . An oral care composition according to  claim 2 , wherein the apatite species is based on the formula M 5 (PO 4 ) 3 X, wherein M is Ca, Sr, Zn or Mg, and X is F, Cl or OH. 
     
     
         4 . An oral care composition according to  claim 2 , wherein the apatite species is a substituted or unsubstituted hydroxyapatite or a substituted or unsubstituted fluorapatite. 
     
     
         5 . An oral care composition according to  claim 2 , wherein the apatite species is selected from calcium hydroxyapatite, strontium hydroxyapatite, calcium hydroxycarbonated apatite, strontium hydroxycarbonated apatite, calcium fluorapatite, strontium fluorapatite, mixed strontium calcium apatites or a mixed hydroxyfluorapatite, zinc substituted hydroxyapatite, zinc carbonated hydroxyapatite, zinc fluorapatite, octacalcium phosphate, or a mixture of any two or more thereof. 
     
     
         6 . An oral care composition according to  claim 2 , wherein the apatite is present in an amount of from about 0.5 to about 30 weight percent of the composition, and/or the apatite has a particle size distribution, where at least about 3% of the mass of the particles have a size less than about 5 microns and where the apatite has a crystallite size of less than about 200 nm, as determined using Scherrer Line broadening. 
     
     
         7 . An oral care composition according to  claim 1 , wherein the source of fluoride ion is selected from sodium fluoride, potassium fluoride, disodium monofluorophosphate, tin(II)fluoride, dipotassium fluorophosphates, calcium fluorophosphates, calcium fluoride, ammonium fluoride, aluminium fluoride, hexadecyl ammonium fluoride, 3-(N-hexadecyl-N-2-hydroxy-ethylammonio) ammonium difluoride, N,N′,N′-Tris(polyoxyethylene)-N-hexadecyl-propylenediaminedihydrofluoride disodium hexafluorosilicate, dipotassiumhexafluorosilicate, ammonium hexafluorosilicate, magnesium hexafluorosilicate or ammonium fluorophosphates, or any combinations of two or more thereof. 
     
     
         8 . An oral care composition according to  claim 1 , wherein the source of fluoride ion has a concentration between 20 and 1500 ppm as fluorine. 
     
     
         9 . An oral care composition according to  claim 8 , wherein when the composition is to be used as toothpaste, the fluoride concentration is between 300 and 1500 ppm. 
     
     
         10 . An oral care composition according to  claim 8 , wherein when the composition is to be used as mouth wash, the active fluoride concentration is between 5 and 500 ppm. 
     
     
         11 . An oral care composition according to  claim 1 , further comprising a buffer system. 
     
     
         12 . An oral care composition according to  claim 11 , wherein the buffer system comprises one or more selected from acetate, carbonate, citrate or phosphate-containing species. 
     
     
         13 . An oral care composition according to  claim 1 , wherein the pH of the composition is between about 6.0 and about 8.0. 
     
     
         14 . An oral care composition according to  claim 1 , wherein when the composition is a mouth wash or oral rinse, it further comprises a linear polysaccharide polymer. 
     
     
         15 . An oral care composition according to  claim 14 , wherein the linear polysaccharide polymer is a linear polysaccharide gum, wherein one or more hydroxyl groups on the monosaccharide is substituted with a functional group comprising a group selected from a carboxyl group (R—COOH), an acyl group (RCO—) or a sulphate group (R—OSO 3   − ). 
     
     
         16 . An oral care composition according to  claim 1  in the remineralisation of teeth or in the treatment of dentine hypersensitivity. 
     
     
         17 . A toothpaste, oral spray, mouthwash or oral rinse formulation comprising an oral care composition according to  claim 1 . 
     
     
         18 . (canceled) 
     
     
         19 . (canceled) 
     
     
         20 . (canceled) 
     
     
         21 . A method of cleaning teeth and mucous membranes of the oral cavity of a subject, or perfuming them or protecting them in order to keep them in good condition, comprising applying an oral care composition according to  claim 1 .