Epithelial ion channel (enac) blockers to treat psoriasis

Abstract

Methods of treatment for psoriasis, and compositions for use in such methods are provided. An effective dose of an epithelial ion channel (ENAC) blocker is administered to an individual suffering from psoriasis. ENAC blockers, including without limitation Benzamil, can reduce thickened cutaneous psoriatic plaques.

What is claimed is: 
     
         1 . A method of treating psoriasis in a subject, the method comprising:
 administering to the subject an effective dose of an epithelial ion channel (ENAC) blocker for duration and periodicity sufficient to reduce the symptoms of psoriasis.   
     
     
         2 . The method of  claim 1 , wherein the ENAC blocker is amiloride or a derivative thereof. 
     
     
         3 . The method of  claim 2 , wherein the ENAC blocker is benzyl amiloride. 
     
     
         4 . The method of  claim 1 , wherein the administration is systemic. 
     
     
         5 . The method of  claim 1 , wherein the administration is topical. 
     
     
         6 . The method of  claim 1 , wherein dose is administered to the subject upon a flare of psoriasis. 
     
     
         7 . The method of  claim 1 , wherein the psoriasis is chronic psoriasis. 
     
     
         8 . The method of  claim 1 , wherein the psoriasis is plaque psoriasis. 
     
     
         9 . A composition in a unit dose formulation of an epithelial ion channel (ENAC) suitable for use in the methods of any one of  claims 1 - 8 . 
     
     
         10 . The composition of  claim 9 , further comprising a second therapeutic agent for treatment of psoriasis. 
     
     
         11 . The composition of  claim 9 , wherein the formulation is suitable for topical use. 
     
     
         12 . The composition of  claim 9 , wherein the formulation is suitable for systemic administration.