Two-piece, internal-channel osmotic delivery system flow modulator

Abstract

An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.

1 .- 20 . (canceled) 
     
     
         21 . An implantable delivery system for an active agent formulation, comprising: a reservoir made of an impermeable material; a first chamber in the reservoir containing an osmotic engine; a second chamber in the reservoir containing an active agent formulation; a partition within the reservoir, the partition defining within the reservoir the first chamber containing the osmotic engine and the second chamber containing the active agent formulation; a semipermeable plug disposed at a first end of the reservoir adjacent the first chamber; and a flow modulator, wherein the flow modulator comprises a delivery orifice through which the active agent formulation is delivered, and the flow modulator does not comprise a fill hole through which the active agent formulation can be injected into the second chamber or a vent hole through which gasses may escape from the second chamber. 
     
     
         22 . The implantable delivery system of  claim 21 , wherein the flow modulator is press fitted into a second end of the reservoir adjacent the second chamber.