Cyclosporin compositions

Abstract

Disclosed herein are therapeutic methods, compositions, and medicaments related to cyclosporine.

1 .- 20 . (canceled) 
     
     
         21 . A method comprising topically administering an aqueous solution comprising cyclosporin A to an eye of a mammal in need thereof to enhance or restore lacrimal gland tearing. 
     
     
         22 . The method of  claim 21 , wherein said method increases tear production in a tear-deficient eye. 
     
     
         23 . The method of  claim 21 , wherein said method is effective in treating keratoconjunctivitis sicca. 
     
     
         24 . The method of  claim 21 , wherein said method is effective in treating dry eye disease. 
     
     
         25 . The method of  claim 21  wherein the mammal is a human patient, and wherein less than 10% of human patients suffer burning or stinging when said aqueous solution is administered only once a day for a period of three months. 
     
     
         26 . The method of  claim 21  wherein the mammal is a human patient, and wherein less than 10% of human patients suffer ocular burning when said aqueous solution is administered only once a day for a period of three months. 
     
     
         27 . The method of  claim 21  wherein the aqueous solution is administered only once a day. 
     
     
         28 .- 39 . (canceled) 
     
     
         40 . The method of  claim 21 , wherein the cyclosporin A is present in the aqueous solution at a concentration of from about 0.0001% (w/v) to less than about 0.05% (w/v).