Compositions and methods for disinfecting and cleaning contact lenses

Abstract

This invention relates generally to disinfection and cleaning systems for medical devices. In a preferred embodiment, the invention relates to compositions, methods and articles for simultaneously cleaning and disinfecting contact lenses. The present invention is directed to ophthalmic compositions containing one or more block copolymers referred to as (polyoxyethylene)-(poly-oxybutylene) block copolymers (“PEO-PBO”). The invention is particularly directed to the use of PEO-PBO di-block copolymers as non-foaming wetting agents in peroxide-based compositions for disinfecting contact lenses.

1 - 18 . (canceled) 
     
     
         19 . A composition for disinfecting a contact lens, comprising about 0.5 w/v % to about 6 w/v % by weight hydrogen peroxide, at least one poly(oxyethylene)-poly(oxybutylene) di-block copolymer and an effective amount of a poly (oxyethylene)-poly (oxypropylene) block copolymer having the structure: 
       
         
           
           
               
               
           
         
         wherein x and y are integers reflecting the respective polypropylene oxide and polyethylene oxide blocks of said copolymer; and the polyoxyethylene component of the block copolymer constitutes less than 50 weight percent of the block copolymer, wherein the poly(oxyethylene)-poly(oxybutylene) di-block copolymer is of the formula (EO) m (BO) n , wherein EO is oxyethylene and BO is oxybutylene, and wherein m is an integer having an average value of 5 to 15 and n is an integer having an average value of 2 to 10, wherein the composition is incapable of foaming at any time within a disinfection cycle carried out in a disinfection cup having a platinum-coated plastic disk that catalytically decomposes hydrogen peroxide generating oxygen gas bubbles excessively to cause overflow of the composition from the disinfection cup. 
       
     
     
         20 . A composition according to  claim 19 , wherein m is no less than n. 
     
     
         21 . A composition according to  claim 20 , wherein the ratio of m to n is in the range of about 1:1 to about 3:1. 
     
     
         22 . A composition according to  claim 21 , wherein the ratio of m to n is in the range of about 1.5:1 to about 2:1. 
     
     
         23 . A composition according to  claim 19 , wherein the poly(oxyethylene)-poly(oxybutylene) di-block copolymer has a molecular weight in the range of 400 to 1,200 Daltons. 
     
     
         24 . A composition according to  claim 23 , wherein the poly(oxyethylene)-poly(oxybutylene) di-block copolymer has a molecular weight in the range of 700 to 900 Daltons. 
     
     
         25 . A composition according to  claim 19 , wherein the poly (oxyethylene)-poly (oxybutylene) di-block copolymer is of the formula: 
       
         
           
           
               
               
           
         
         wherein R is selected from the group consisting of hydrogen, methyl, ethyl, propyl and butyl; m is an integer having an average value of 5 to 15; and n is an integer having an average value of 2 to 10. 
       
     
     
         26 . A composition according to  claim 25 , wherein R is methyl; m has an average value of 10; and n has an average value of 5. 
     
     
         27 . A composition according to  claim 19 , wherein the polyoxyethylene component of the block copolymer in poly (oxyethylene)-poly (oxypropylene) block copolymer constitutes about 40 weight percent of the block copolymer. 
     
     
         28 . A composition according to  claim 19 , wherein the molecular weight of the polyoxypropylene in block poly (oxyethylene)-poly (oxypropylene) block copolymer is from about 1200 and about 3100. 
     
     
         29 . A composition according to  claim 19 , wherein the molecular weight of the polyoxypropylene block in poly (oxyethylene)-poly (oxypropylene) block copolymer is about 1700. 
     
     
         30 . A composition according to  claim 19 , wherein the poly (oxyethylene)-poly (oxypropylene) block copolymer is present in the range of about 0.005% to about 0.8%. 
     
     
         31 . A composition according to  claim 19 , wherein said poly (oxyethylene)-poly (oxypropylene) block copolymer is present less than 0.1%. 
     
     
         32 . A method of disinfecting a contact lens comprising the steps of:
 (a) contacting a contact lens with an aqueous solution of about 0.5 w/v % to about 6 w/v % by weight hydrogen peroxide, at least one poly(oxyethylene)-poly(oxybutylene) di-block copolymer, and an effective amount of a poly (oxyethylene)-poly (oxypropylene) block copolymer having the structure:   
       
         
           
           
               
               
           
         
         wherein x and y are integers reflecting the respective polypropylene oxide and polyethylene oxide blocks of said copolymer; and the polyoxyethylene component of the block copolymer constitutes less than 50 weight percent of the block copolymer, wherein the poly(oxyethylene)-poly(oxybutylene) di-block copolymer is of the formula (EO) m (BO) n , wherein EO is oxyethylene and BO is oxybutylene, and wherein m is an integer having an average value of 5 to 15 and n is an integer having an average value of 2 to 10, wherein the composition is incapable of foaming at any time within a disinfection cycle carried out in a disinfection cup having a platinum-coated plastic disk that catalytically decomposes hydrogen peroxide generating oxygen gas bubbles excessively to cause overflow of the composition from the disinfection cup, and 
         (b) neutralizing said hydrogen peroxide by catalytic decomposition. 
       
     
     
         33 . A method of disinfecting a contact lens as claimed in  claim 32 , wherein the step of neutralizing comprises contacting said solution with a metal catalyst. 
     
     
         34 . A method of disinfecting a contact lens as claimed in  claim 32 , wherein the lens is ready for insertion into the eye without a step of manually rubbing the lens.