US2017138888A1PendingUtilityA1
Apparatus and method for measuring erythrocyte sedimentation rate
Assignee: GWANGJU INST SCIENCE & TECHPriority: Nov 12, 2015Filed: Nov 11, 2016Published: May 18, 2017
Est. expiryNov 12, 2035(~9.3 yrs left)· nominal 20-yr term from priority
G01N 15/05G01N 33/491G01N 27/3275G01N 33/48707G01N 33/49
49
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Claims
Abstract
An apparatus and method for measuring an erythrocyte sedimentation rate based on a change in conductivity of blood over time. The apparatus for measuring an erythrocyte sedimentation rate may include: a chamber for holding blood; a pair of electrodes being partially or completely brought into contact with the blood; and a conductivity meter measuring the conductivity through the pair of electrodes. The apparatus and method according to the present invention are less time-consuming than the Westergren method and can acquire a variety of information (for example, hematocrit, dynamics of the sedimentation rate and aggregation of erythrocytes, a relationship between the sedimentation rate and aggregation of erythrocytes, and the like).
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 . An apparatus for measuring an erythrocyte sedimentation rate based on a change in conductivity of blood over time, comprising:
a chamber for holding blood; a pair of electrodes partially or completely brought into contact with the blood; and a conductivity meter measuring the conductivity through the pair of electrodes.
2 . The apparatus according to claim 1 , wherein the pair of electrodes is placed on a bottom surface of the chamber.
3 . The apparatus according to claim 1 , wherein the change in conductivity is found based on a difference between conductivities measured at two points of time.
4 . The apparatus according to claim 3 , wherein the two points of time are selected from a time section after the conductivity starts to decrease.
5 . The apparatus according to claim 4 , wherein the erythrocyte sedimentation rate is measured through comparison of the change in conductivity with an erythrocyte sedimentation rate measured by the Westergren method.
6 . The apparatus according to claim 5 , wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
Δσ=λ W γ
where Δσ denotes a difference (unit: S/m) between conductivities of the blood measured at predetermined points of time, W denotes an erythrocyte sedimentation rate (unit: mm/h) measured by the Westergren method, and λ and γ denote fitting parameters, wherein the fitting parameters are calculated by regression analysis.
7 . The apparatus according to claim 6 , wherein the predetermined points of time are 200 seconds and 400 seconds, respectively, and Δσ is calculated by σ 200 -σ 400 , wherein σ 200 denotes a conductivity measured when 200 seconds elapse after erythrocytes start to settle, and σ 400 denotes a conductivity measured when 400 seconds elapse after erythrocytes start to settle.
8 . The apparatus according to claim 1 , wherein the conductivity meter measures impedance between the pair of electrodes to find the conductivity.
9 . The apparatus according to claim 5 , wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
Δσ=λ log(1+ W )
where Δσ denotes a difference (unit: S/m) between conductivities of the blood measured at predetermined points of time, W denotes an erythrocyte sedimentation rate (unit: mm/h) measured by the Westergren method, and λ denotes fitting parameters, wherein the fitting parameters are calculated by regression analysis.
10 . The apparatus according to claim 5 , wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
Δ
σ
=
λ
W
W
+
γ
where Δσ denotes a difference (unit: S/m) between conductivities of the blood measured at predetermined points of time, W denotes an erythrocyte sedimentation rate (unit: mm/h) measured by the Westergren method, and λ and γ denote fitting parameters, wherein the fitting parameters are calculated by regression analysis.
11 . The apparatus according to claim 5 , wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
Δ
σ
=
λ
[
(
1
γ
)
2
-
(
1
W
+
γ
)
2
]
where Δσ denotes a difference (unit: S/m) between conductivities of the blood measured at predetermined points of time, W denotes an erythrocyte sedimentation rate (unit: mm/h) measured by the Westergren method, and λ and γ denote fitting parameters, wherein the fitting parameters are calculated by regression analysis.
12 . A method for measuring an erythrocyte sedimentation rate based on a change in conductivity of blood over time, comprising:
introducing blood into a chamber; and measuring conductivity of the blood using a pair of electrodes.
13 . The method according to claim 12 , wherein the pair of electrodes is placed in a bottom surface of the chamber.
14 . The method according to claim 12 , wherein the change in conductivity is found based on a difference between conductivities measured at two points of time.
15 . The method according to claim 14 , wherein the two points of time are selected from a time section after the conductivity starts to decrease.
16 . The method according to claim 15 , wherein the erythrocyte sedimentation rate is measured through comparison of the change in conductivity with an erythrocyte sedimentation rate measured by the Westergren method.
17 . The method according to claim 16 , wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
Δσ=λ W γ
where Δσ denotes a difference (unit: S/m) between conductivities of the blood measured at predetermined points of time, W denotes an erythrocyte sedimentation rate (unit: mm/h) measured by the Westergren method, and λ and γ denote fitting parameters, wherein the fitting parameters are calculated by regression analysis.
18 . The method according to claim 16 , wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
Δσ=λ log(1+ W )
where Δσ denotes a difference (unit: S/m) between conductivities of the blood measured at predetermined points of time, W denotes an erythrocyte sedimentation rate (unit: mm/h) measured by the Westergren method, and λ denotes fitting parameters, wherein the fitting parameters are calculated by regression analysis.
19 . The method according to claim 16 , wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
Δ
σ
=
λ
W
W
+
γ
where Δσ denotes a difference (unit: S/m) between conductivities of the blood measured at predetermined points of time, W denotes an erythrocyte sedimentation rate (unit: mm/h) measured by the Westergren method, and λ and γ denote fitting parameters, wherein the fitting parameters are calculated by regression analysis.
20 . The method according to claim 16 , wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
Δ
σ
=
λ
[
(
1
γ
)
2
-
(
1
W
+
γ
)
2
]
where Δσ denotes a difference (unit: S/m) between conductivities of the blood measured at predetermined points of time, W denotes an erythrocyte sedimentation rate (unit: mm/h) measured by the Westergren method, and λ and γ denote fitting parameters, wherein the fitting parameters are calculated by regression analysis.Join the waitlist — get patent alerts
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