US2017136057A1PendingUtilityA1
Ophthalmic compositions with improved dessication protection and retention
Est. expiryMay 4, 2032(~5.8 yrs left)· nominal 20-yr term from priority
A61K 47/32A61K 47/36A61P 27/02A61P 27/04A61K 9/08A61K 9/0048A61K 47/10A61K 47/02A61K 47/26A61K 31/736A61K 31/728A61K 31/047
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Claims
Abstract
The present invention relates to artificial tear compositions and ophthalmic compositions suitable for drug delivery. In one embodiment of the present invention, the compositions comprise a galactomannan polymer such as guar or hydroxypropyl guar, hyaluronic acid, and a cis-diol such as sorbitol. In a preferred embodiment, the compositions also comprise a borate compound.
Claims
exact text as granted — not AI-modified1 : An ophthalmic composition comprising 0.1 to 0.2 w/v % galactomannan, 0.1 to 0.2 w/v % hyaluronic acid, and 1.0 to 2.0 w/v % cis-diol, and wherein said galactomannan is hydroxypropyl guar and said cis-diol is sorbitol.
2 : A composition according to claim 1 comprising 0.17 to 0.18 w/v % hydroxypropyl guar, 0.13 to 0.17 w/v % sodium hyaluronate, and 1.4 w/v % sorbitol.
3 : A composition according to claim 1 wherein said cis-diol is present at a concentration of about 1.4 w/v %.
4 : A composition according to claim 1 wherein further comprising borate.
5 : A composition according to claim 1 further comprising a demulcent selected from the group consisting of:
glycerin, polyvinyl pyrrolidone, polyethylene oxide, polyethylene glycol, propylene glycol, polyacrylic acid, and combinations thereof.
6 : A composition according to claim 5 wherein said demulcent is polypropylene glycol or polyethylene glycol.
7 : A composition according to claim 1 further comprising a pharmaceutically active compound.
8 : A method for treating ophthalmic disease which comprises administering to a subject in need of such treatment a composition according to claim 1 .
9 : A method according to claim 8 , wherein the ophthalmic disease is dry eye.
10 : A composition according to claim 4 , wherein said boric acid is present at a concentration of 0.1 to 1.8 w/v %.
11 : A composition according to claim 5 , wherein said demulcent is polyethylene glycol and propylene glycol.
12 : A composition according to claim 11 , wherein said polyethylene glycol is present at a concentration of 0.4 w/v %.
13 : A composition according to claim 11 wherein said propylene glycol is present at a concentration of 0.3 w/v % hyaluronic acid.
14 : A composition according to claim 1 comprising 0.17 to 0.18 w/v % hydroxypropyl guar and 0.13 to 0.17 w/v % hyaluronic acid.
15 : A composition according to claim 1 wherein the osmolality of said composition is 210-320 milliosmoles per kilogram (mOsm/kg).
16 : A composition according to claim 1 wherein said composition has a pH of 6.5 to 8.Join the waitlist — get patent alerts
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