US2017114086A1PendingUtilityA1

2'- substituted carba-nucleoside analogs for antiviral treatment

Assignee: GILEAD SCIENCES INCPriority: Mar 13, 2012Filed: Sep 30, 2016Published: Apr 27, 2017
Est. expiryMar 13, 2032(~5.6 yrs left)· nominal 20-yr term from priority
A61P 31/14A61P 31/16A61P 43/00A61P 31/00A61K 31/706C07H 19/23A61K 45/06C07H 19/12A61M 2202/30A61M 15/00C07D 487/04
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Claims

Abstract

Provided are compounds of Formula I, as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.

Claims

exact text as granted — not AI-modified
1 - 64 . (canceled) 
     
     
         65 . A compound of Formula III: 
       
         
           
           
               
               
           
         
         wherein:
 R 8  is NH 2 , OMe, OCH 2 CH 3  or ═O; and 
 R 9  is NH 2 , H, or F; 
 
         or a pharmaceutically acceptable salt, solvate, or ester thereof. 
       
     
     
         66 . The compound of  claim 65  selected from the group consisting of 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt, solvate, or ester thereof.

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