US2017114039A1PendingUtilityA1
Inhibitors of bruton's tyrosine kinase
Est. expiryJun 8, 2032(~5.9 yrs left)· nominal 20-yr term from priority
Inventors:Brian T. HopkinsXiongwei CaiTimothy ChanPatrick R. ConlonMichael HumoraTracy J. JenkinsJ. Michael MacpheeXianglin ShiRoss A. MillerAndrew Thompson
C07D 207/16C07D 207/28C07D 211/56C07D 401/04C07D 401/14C07B 2200/13
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Claims
Abstract
The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 - 40 . (canceled)
41 . A solid form of Compound I:
wherein the solid form is amorphous or crystalline.
42 . A method of treating a disorder selected from the group consisting of rheumatoid arthritis, lupus erythematosus, atopic dermatitis, leukemia and lymphoma comprising administering to a subject an effective amount of the solid form of claim 41 .
43 . The method of claim 42 , wherein the disorder is rheumatoid arthritis.
44 . The method of claim 42 , wherein the disorder is systemic lupus erythematosus.
45 . The method of claim 42 , wherein the disorder is atopic dermatitis.
46 . The method of claim 42 , wherein the disorder is leukemia or lymphoma.
47 . A compound selected from the group consisting of
wherein —OR LG is a suitable leaving group; and
PG is a suitable protecting group.
48 . The compound of claim 47 wherein the compound is:
wherein —OR LG is a suitable leaving group.
49 . The compound of claim 47 wherein the compound is:
wherein —OR LG is a suitable leaving group.
50 . The compound of claim 47 wherein the compound is:
wherein PG is a suitable protecting group.
51 . The compound of claim 47 wherein the compound is:
wherein —OR LG is a suitable leaving group.
52 . The compound of claim 47 wherein the compound is:
wherein PG is a suitable protecting group.
53 . The compound of claim 47 wherein the compound is:
wherein —OR LG is a suitable leaving group.
54 . The compound of claim 47 , wherein —OR LG is a C 1-6 aliphatic alkoxy group.
55 . The compound of claim 47 , wherein PG is a Boc group.
56 . The compound of claim 47 wherein the compound is:
57 . The compound of claim 47 wherein the compound is:Join the waitlist — get patent alerts
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