US2017112813A1PendingUtilityA1

Methods of treating autophagy-associated disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits

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Assignee: STC UNMPriority: May 10, 2011Filed: Oct 6, 2016Published: Apr 27, 2017
Est. expiryMay 10, 2031(~4.8 yrs left)· nominal 20-yr term from priority
Inventors:Vojo P. DereticEliseo CastilloSteven BradfuteLarry A. Sklar
A61K 31/65A61K 31/546A61K 31/54A61K 31/436G01N 2333/9015A61K 31/4184A61K 31/136A61K 31/12A61K 31/519A61K 31/517G01N 33/56972A61K 31/473A61K 31/522G01N 33/6893A61K 31/472A61K 31/4365A61K 31/5685A61K 31/585A61K 31/4535A61P 29/00C07K 16/18
56
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Claims

Abstract

The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.

Claims

exact text as granted — not AI-modified
1 - 85 . (canceled) 
     
     
         86 . A pharmaceutical composition for use in the treatment of tuberculosis comprising:
 (a) an effective amount of at least one compound as an autophagy modulator selected from the group consisting of rapamycin, flubendazole, bromhexine and curcumin; and   (b) an effective amount of an anti-tuberculosis agent, further in combination with a pharmaceutically-acceptable carrier, additive and/or excipient.   
     
     
         87 . The composition according to  claim 86  wherein said compound is rapamycin, flubendazole, bromhexine or a mixture thereof. 
     
     
         88 . The composition according to  claim 86  wherein said compound is rapamycin, bromhexine, curcumin or a mixture thereof. 
     
     
         89 . The composition according to  claim 86  wherein said compound is rapamycin, flubendazole, curcumin or a mixture thereof. 
     
     
         90 . The composition according to  claim 86  wherein said compound is flubendazole, bromhexin, curcumin or a mixture thereof. 
     
     
         91 . The composition according to  claim 86  wherein said compound is flubendazole, rapamycin or a mixture of flubendazole and rapamycin. 
     
     
         92 . The composition according to  claim 86  wherein said compound is rapamycin, curcumin or a mixture of rapamycin and curcumin. 
     
     
         93 . The composition according to  claim 86  wherein said autophagy modulator comprises rapamycin, brombexine or a mixture of rapamycin and bromhexine. 
     
     
         94 . The composition according to  claim 86  wherein said autophagy modulator comprises rapamycin, brombexine, curcumin or a mixture thereof. 
     
     
         95 . The composition according to  claim 86  wherein said autophagy modulator comprises rapamycin, flubendazole and brombexine. 
     
     
         96 . The composition according to  claim 86  wherein said autophagy modulator comprises flubendazole, rapamycin and curcumin. 
     
     
         97 . The composition according to claim  85  comprising flubendazole, bromhexine, rapamycin and curcumin. 
     
     
         98 . A method of treating tuberculosis in a patient in need comprising administering to said patient a composition according to  claim 86 . 
     
     
         99 . A method of treating tuberculosis in a patient in need comprising administering to said patient a composition according to  claim 87 . 
     
     
         100 . A method of treating tuberculosis in a patient in need comprising administering to said patient a composition according to  claim 88 . 
     
     
         101 . A method of treating tuberculosis in a patient in need comprising administering to said patient a composition according to  claim 89 . 
     
     
         102 . A method of treating tuberculosis in a patient in need comprising administering to said patient a composition according to  claim 90 . 
     
     
         103 . A method of treating tuberculosis in a patient in need comprising administering to said patient a composition according to  claim 91 . 
     
     
         104 . A method of treating tuberculosis in a patient in need comprising administering to said patient a composition according to  claim 92 . 
     
     
         105 . A method of treating tuberculosis in a patient in need comprising administering to said patient a composition according to  claim 93 .

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