US2017107206A1PendingUtilityA1

Modulators of atp-binding cassette transporters

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Assignee: VERTEX PHARMAPriority: Nov 8, 2005Filed: Jun 3, 2016Published: Apr 20, 2017
Est. expiryNov 8, 2025(expired)· nominal 20-yr term from priority
Inventors:Sara S. Hadida RuahMatthew HamiltonMark MillerPeter D.J. GrootenhuisBrian BearJason MccartneyJinglan Zhou
A61P 7/00A61P 5/50A61P 5/00A61P 7/02A61P 3/06A61P 43/00A61P 5/18A61P 9/00A61P 3/10A61P 7/12A61P 5/16A61P 35/00A61P 3/08A61P 5/14A61P 3/00A61P 25/16A61P 25/28A61P 25/00A61P 27/02A61P 27/04A61P 25/14A61P 13/02A61P 19/08A61P 21/04A61P 19/04A61P 17/00A61P 21/02A61P 13/00A61P 19/00A61P 1/00A61P 11/00A61P 13/12A61P 21/00C07D 317/12A61K 31/47A61K 31/501A61K 31/4545A61K 31/497A61K 31/506C07D 405/14A61K 31/443G01N 33/6872A61K 31/5377A61K 31/4525A61K 31/444A61K 45/06C07K 14/4712C07D 405/12A61K 31/4709A61K 31/496
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Claims

Abstract

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Claims

exact text as granted — not AI-modified
1 - 52 . (canceled) 
     
     
         53 . A compound having the following chemical formula:

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