Composition for preventing and treating male infertility, containing mixed herbal extract as active ingredient and use thereof

Abstract

A composition and health functional food for treating male infertility using a mixed herbal mixture. Through an in vitro sperm mobility promotion effect evaluation method experiment for investigating effects of an herbal extract of Morinda officinalis , Cuscuta seed, and/or Allium cepa of the present invention on changes in sperm count and mobility in human semen, it was verified that the composition increased sperm mobility. In addition, through an in vivo varicocele animal model evaluation method for investigating effects of the herbal extract on changes in sperm count and mobility in an in vivo varicocele animal model, it was verified that the composition samples of the present invention increased the sperm count in the semen obtained from spermiducts of a sample-administered group among varicocele-induced groups. Therefore, the herbal extract can be used in a pharmaceutical composition, health functional food, and health supplement food for treating male infertility.

1 . A pharmaceutical composition comprising a combination of extracts from  Morinda Officinalis  root,  Cuscuta  seed, and  Allium cepa  bulb as an active ingredient for treating male infertility. 
     
     
         2 . The pharmaceutical composition of  claim 1 , wherein the combination of extracts from  Morinda Officinalis  root,  Cuscuta  seed, and  Allium cepa  bulb has a range of mixed ratios based on the dried weight of each herb of 0.01-100:0.01-1:1-100 (w/w). 
     
     
         3 . The pharmaceutical composition of  claim 1 , wherein the male infertility is selected from the group consisting of an adverse response of an anti-cancer agent, azoospermia, oligospermia, asthenospermia, and teratospermia. 
     
     
         4 . A health functional food comprising a combination of extracts from  Morinda Officinalis  root,  Cuscuta  seed, and  Allium cepa  bulb as an active ingredient for the improvement of male infertility. 
     
     
         5 . The health functional food of  claim 4 , wherein the health food is selected from the group consisting of powder, granule, tablet, capsule, pill, suspension, emulsion, syrup, tea bag, leached tea, or beverage type. 
     
     
         6 . (canceled) 
     
     
         7 . A method of treatment of male infertility comprising administering the pharmaceutical composition of  claim 1  to a subject in need of treatment of male infertility. 
     
     
         8 . (canceled) 
     
     
         9 . The method of  claim 7 , further comprising the step of:
 obtaining extracts from  Morinda Officinalis  root,  Cuscuta  seed, and  Allium cepa  bulb;   mixing the extracts together to obtain the combination of extracts from  Morinda Officinalis  root,  Cuscuta  seed, and  Allium cepa  bulb; and   administering the combination of extracts to the subject in need of treatment of male infertility.   
     
     
         10 . The method of  claim 8 , wherein the combination of extracts from  Morinda Officinalis  root,  Cuscuta  seed, and  Allium cepa  bulb has a range of mixed ratios based on the dried weight of each herb of 0.01-100:0.01-1:1-100 (w/w). 
     
     
         11 . The method of  claim 7 , wherein the male infertility is selected from the group consisting of an adverse response of an anti-cancer agent, azoospermia, oligospermia, asthenospermia, and teratospermia. 
     
     
         12 . A method of manufacturing a medicament for the treatment of male infertility in a human or mammal comprising the steps of
 extracting a composition from  Morinda Officinalis  root,   extracting a composition from  Cuscuta  seed, and   extracting a composition from  Allium cepa  bulb; and   mixing the compositions together at mixed ratios ranging from 0.01-100:0.01-1:1-100, based on the dried weight of each composition (w/w).