Nutritional compositions for modulating inflammation including exogenous vitamin k2

Abstract

Nutritional compositions and methods of making and using the nutritional compositions are provided. In a general embodiment, a nutritional composition includes exogenous vitamin K2. The nutritional compositions may further include an additional component selected from the group consisting of phosphorus, magnesium, zinc, iron, copper, manganese, calcium, vitamin D, osteopontin and combinations thereof.

The invention is claimed as follows: 
     
         1 . A method of modulating the effects of inflammation, the method comprising:
 administering a nutritional composition comprising an effective amount of exogenous vitamin K 2  to a patient having at least one condition selected from the group consisting of developmental delay, failure-to-thrive, Crohn's disease, Crohn's Disease-associated osteopenia, colitis, ulcerative colitis, celiac disease, gluten intolerance, neuromuscular dysfunction, renal dysfunction, androgen deficiency, severe food allergy, short bowel syndrome, and combinations thereof.   
     
     
         2 . The method of  claim 1  wherein the exogenous vitamin K2 is selected from the group consisting of MK-4, MK-7 and combinations thereof. 
     
     
         3 . The method of  claim 1 , wherein the exogenous vitamin K2 is MK-7. 
     
     
         4 . The method of  claim 1 , wherein the effective amount of exogenous vitamin K2 is from about 1 μg to about 100 μg per day. 
     
     
         5 . The method of  claim 1 , wherein the effective amount of exogenous vitamin K2 is from about 20 μg to about 90 μg per day. 
     
     
         6 . The method of  claim 1 , wherein the effective amount of exogenous vitamin K2 is from about 50 μg to about 80 μg per day. 
     
     
         7 . The method of  claim 1 , wherein the nutritional composition is in an administrable form selected from the group consisting of pharmaceutical formulations, nutritional formulations, tube-feed formulations, dietary supplements, functional foods and beverage products. 
     
     
         8 . The method of  claim 1 , the nutritional composition further comprising at least one component selected from the group consisting of prebiotic, probiotics, symbiotic, amino acid, protein, nucleotides, a fish oil, non-marine omega-3 fatty acid containing dietary fat source, phytonutrients, antioxidant, and combinations thereof. 
     
     
         9 . The nutritional composition of  claim 8 , wherein the amino acid is selected from the group consisting of proline, hydroxyproline, hydroxytyrosine, hydroxylysine and hydroxyserine and combinations thereof. 
     
     
         10 . The method of  claim 1 , wherein the modulation of the effects of inflammation is a reducing of the effects of inflammation. 
     
     
         11 . The method of  claim 1 , wherein the modulation of the effects of inflammation is a preventing of the effects of inflammation. 
     
     
         12 . The method of  claim 1 , wherein the modulation of the effects of inflammation is decreasing a rise of plasma TNF-α under conditions of inflammation. 
     
     
         13 . The method of  claim 1 , wherein the modulation of the effects of inflammation is blunting a drop in phosphorylation for IKKα/β and NFκB p65 induction under conditions of inflammation. 
     
     
         14 . The method of  claim 1 , wherein the modulation of the effects of inflammation is abrogating a decrease in 4E-BP1(Thr-37) and ribosomal protein S6 phosphorylation under conditions of inflammation. 
     
     
         15 . The method of  claim 1 , wherein the modulation of the effects of inflammation is preserving the fractional rate of mixed muscle protein synthesis under conditions of inflammation. 
     
     
         16 . The method of  claim 1 , wherein the patient is a child.