Combination vaccines with serogroup b meningococcus and d/t/p

Abstract

Serogroup B meningococcus antigens can successfully be combined with diphtheria, tetanus and pertussis toxoids (“DTP”) to provide effective combination vaccines for protecting against multiple pathogens. These combinations are effective with a range of different adjuvants, and with both pediatric-type and booster-type DTP ratios. The adjuvant can improve the immune response which the composition elicits; alternatively, by including an adjuvant it is possible for the compositions to have a relatively lower amount of antigen while nevertheless having immunogenicity which is comparable to unadjuvanted combination vaccines.

We claim: 
     
         1 : An immunogenic composition, comprising: (a) a serogroup B meningococcus immunogen; and (b) a diphtheria toxoid, a tetanus toxoid, and a pertussis toxoid, wherein the diphtheria toxoid is present in an excess relative to tetanus toxoid as measured in Lf units. 
     
     
         2 : The composition of  claim 1 , further comprising an adjuvant.