Compositions based on plant extracts for inhibition of the 5-alpha reductase

Abstract

The present invention refers to nutraceutical, cosmetic or pharmaceutical compositions based on a combination of vegetal extracts from flowers or fruits of Opuntia ficus and Oryza sativa (Black rice) for inhibition of the 5-alpha reductase. In particular, the preparations according to the invention are useful in prevention or treatment of benign prostatic hypertrophy or hyperplasia, of androgenic alopecia and acne.

1 - 10 . (canceled) 
     
     
         11 . Nutraceutical or pharmaceutical composition comprising a combination of an extract of  Opuntia ficus indica  flowers and/or fruits and an extract of  Oryza sativa  (Black rice) as active principles, together with pharmaceutically acceptable adjuvants and/or excipients, for use in the prevention and treatment of diseases or disorders related to the inhibition of the enzymatic activity of the 5-alpha reductase selected between benign prostatic hyperplasia, androgenic alopecia or acne. 
     
     
         12 . Nutraceutical or pharmaceutical composition for use according to  claim 11 , wherein the extract of  Opuntia ficus indica  flowers and/or fruits and the  Oryza sativa  (Black rice) extract are in a reciprocal weight ratio comprised between 1:1 and 1:25, preferably 1:10 or 1:20. 
     
     
         13 . Nutraceutical or pharmaceutical composition for use according to  claim 11 , for use in the prevention and treatment of benign prostatic, which is suitable for the oral administration. 
     
     
         14 . Nutraceutical or pharmaceutical composition for use according to  claim 13 , in the form of oral solution, oral emulsion, oral suspension, capsule, tablet, powder or granulate. 
     
     
         15 . Cosmetic or pharmaceutical composition for use according to  claim 11 , for use in the prevention or treatment of androgenic alopecia or acne, which is suitable for topical or oral administration. 
     
     
         16 . Cosmetic or pharmaceutical composition for use according to  claim 15 , suitable for the topical application in the form of cream, pomade, ointment, foam, lotion, gel or spray. 
     
     
         17 . Composition suitable for the oral administration for use according to  claim 13 , wherein the total concentration of the extracts is comprised between 10%-90% in weight percentage of the final composition. 
     
     
         18 . Cosmetic or pharmaceutical composition suitable for the topical application for use according to  claim 15 , wherein the total concentration of the extracts is comprised between 0.5%-5% in weight percentage of the final composition. 
     
     
         19 . A combined preparation of an extract of  Opuntia ficus indica  flowers and/or fruits and an extract of  Oryza sativa  (Black rice) for simultaneous or separate use in the prevention or treatment of diseases or disorders related to the inhibition of the enzymatic activity of the 5-alpha reductase, selected between benign prostatic hyperplasia, androgenic alopecia or acne. 
     
     
         20 . A combined preparation for use according to  claim 19 , suitable for topical or oral administration.