Composition for treating or preventing metabolic disease, containing, as active ingredient, extracellular vesicles derived from akkermansia muciniphila bacteria

Abstract

The present invention relates to a pharmaceutical and food composition for treating, preventing, or alleviating a metabolic disease, containing, as an active ingredient, extracellular vesicles derived from Akkermansia muciniphila . The composition of the present invention can be used as a pharmaceutical/food composition and the like for treating, preventing, or alleviating metabolic diseases, in particular metabolic diseases such as obesity, diabetes, hyperlipidemia, arteriosclerosis, and hypertension, occurring or exacerbated due to a high fat diet. In addition, in the present invention, a fermented food itself, prepared by adding Akkermansia muciniphila , can be used for the purpose of preventing or alleviating a metabolic disease occurring or exacerbated due to a high fat diet.

1 . A method for treating a metabolic disease, comprising:
 administering a pharmaceutical composition including  Akkermansia muciniphila -derived extracellular vesicles to a subject.   
     
     
         2 . The method according to  claim 1  wherein the extracellular vesicles are naturally or artificially secreted from the  Akkermansia muciniphila.    
     
     
         3 . The method according to  claim 1 , wherein the extracellular vesicles have an average diameter of 20 to 300 nm. 
     
     
         4 . The method according to  claim 1 , wherein the metabolic disease is selected from the group consisting of obesity, diabetes, hyperlipidema, arteriosclerosis, and hypertension. 
     
     
         5 . A method for alleviating a metabolic disease, comprising:
 administering a food composition including  Akkermansia muciniphila  -derived extracellular vesicles to a subject.   
     
     
         6 . The method according to  claim 5 , wherein the extracellular vesicles are naturally or artificially secreted from the  Akkermansia muciniphila . 
     
     
         7 . The method according to  claim 5 , wherein the extracellular vesicles have an average diameter of 20 to 300 nm. 
     
     
         8 . The method according to  claim 5 , wherein the metabolic disease is selected from the group consisting of obesity, diabetes, hyperlipidemia, arteriosclerosis, and hypertension. 
     
     
         9 . The method according to  claim 5 , wherein the food. is a fermented food prepared through fermentation by adding the  Akkermansia muciniphila . 
     
     
         10 . (canceled) 
     
     
         11 . (canceled)