Benzenetricarboxylic acid and methods of use

Abstract

Methods of treating or preventing cancer and/or a neurodegenerative disorder in a subject are provided. The methods comprise administering to a subject a therapeutically effective amount of 1,2,3-benzenetricarboxylic acid or a hydrate or pharmaceutically acceptable salt thereof.

What is claimed is: 
     
         1 . A method of treating or preventing cancer in a subject, comprising:
 administering to the subject an effective amount of a compound of the following structure:   
       
         
           
           
               
               
           
         
       
       or a hydrate or pharmaceutically acceptable salt thereof. 
     
     
         2 . The method of  claim 1 , further comprising administering a second therapeutic agent to the subject. 
     
     
         3 . The method of  claim 2 , wherein the second therapeutic agent is a chemotherapeutic agent. 
     
     
         4 . The method of  claim 1 , wherein the cancer is breast cancer. 
     
     
         5 . The method of  claim 1 , wherein the cancer is lung cancer. 
     
     
         6 . The method of  claim 1 , wherein the cancer is bladder cancer. 
     
     
         7 . A method of treating or preventing a neurodegenerative disorder in a subject, comprising:
 administering to the subject an effective amount of a compound of the following structure:   
       
         
           
           
               
               
           
         
       
       or a hydrate or pharmaceutically acceptable salt thereof. 
     
     
         8 . The method of  claim 7 , wherein the neurodegenerative disorder is Parkinson's disease. 
     
     
         9 . The method of  claim 7 , further comprising administering a second therapeutic agent to the subject. 
     
     
         10 . The method of  claim 9 , wherein the second therapeutic agent is selected from the group consisting of levadopa, a dopamine agonist, an anticholinergic agent, a monoamine oxidase inhibitor, a COMT inhibitor, amantadine, rivastigmine, an NMDA antagonist, a cholinesterase inhibitor, riluzole, an anti-psychotic agent, an antidepressant, and tetrabenazine.