8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions

Abstract

The present invention relates to substituted xanthines of general formula wherein R 1 to R 3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

What is claimed is: 
     
         1 . 1-[(Quinoxalin-6-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-amino-piperidin-1-yl)-xanthine, or an enantiomer, a mixture of enantiomers or a salt thereof. 
     
     
         2 . 3-Methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine. 
     
     
         3 . A physiologically acceptable salt of a compound according to  claim 1  with an inorganic or organic acid or base. 
     
     
         4 . A pharmaceutical composition comprising a compound according to  claim 1  or a physiologically acceptable salt thereof, optionally together with one or more inert carriers and/or diluents.