Protein adsorbent

Abstract

A method for producing a protein adsorbent comprising a substrate and a molecular chain fixed on the surface of the substrate is disclosed. The method comprises, in this order: a dry-heat treatment step of heating a pretreatment adsorbent comprising the substrate and the molecular chain fixed on the surface of the substrate, in which the molecular chain contains a weak electrolytic ion-exchange group; and a wet-heat treatment step of heating the pretreatment adsorbent in a moistened state with a liquid or steam to obtain the protein adsorbent.

What is claimed is: 
     
         1 . A protein adsorbent comprising a substrate and a molecular chain fixed to a surface of the substrate, the molecular chain containing a weak electrolytic ion-exchange group, wherein
 when test treatment in which the protein adsorbent moistened with a 20 mM tris-hydrochloric acid buffer solution containing 1 mol/L sodium chloride is heated at 50° C. for 8 hours is performed, a change ratio of a dynamic adsorption capacity of the protein adsorbent before and after the test treatment is within ±5%.   
     
     
         2 . The protein adsorbent according to  claim 1 , wherein the molecular chain is covalently-bonded to a compound constituting the substrate. 
     
     
         3 . The protein adsorbent according to  claim 1 , wherein the substrate is a porous body. 
     
     
         4 . The protein adsorbent according to  claim 1 , wherein the substrate is hollow fibrous. 
     
     
         5 . The protein adsorbent according to  claim 1 , wherein the weak electrolytic ion-exchange group is a tertiary amino group. 
     
     
         6 . The protein adsorbent according to  claim 1 , wherein the molecular chain is a linear polymer chain formed by graft polymerization. 
     
     
         7 . A module comprising the protein adsorbent according to  claim 1 . 
     
     
         8 . A column comprising the protein adsorbent according to  claim 1 .