Topical gel compositions including poly(monostearoyl glycerol-co-succinate) polymer and methods for enhancing the topical application of a benefit agent

Abstract

A composition comprising: a benefit agent; at least one polymer including a poly(monostearoyl glycerol-co-succinate) polymer; at least one lower alcohol; and at least one co-solvent; and a method for enhancing topical delivery of a benefit agent are disclosed.

1 - 21 . (canceled) 
     
     
         22 . A topical composition comprising:
 ibuprofen;   at least one polymer including a poly(monostearoyl glycerol-co-succinate) polymer;   at least one lower alcohol;   and at least one co-solvent.   
     
     
         23 . The topical composition according to  claim 22 ,
 wherein the at least one lower alcohol is selected from the group consisting of ethyl alcohol, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutyl alcohol, amyl alcohol, benzyl alcohol, octyldocanol, hexyldecanol, butyloctanol, and mixtures thereof; and   wherein the at least one co-solvent is selected from the group consisting of glycerol, polyglycerols, glycols, polyglycols, and mixtures thereof   
     
     
         24 . The topical composition according to  claim 23 , wherein the polyglycerols are selected from the group consisting of diglycerol, triglycerol, tetraglycerol, polycerol-n, where n>4, and mixtures thereof. 
     
     
         25 . The topical composition according to  claim 23 , wherein the glycols are selected from the group consisting of propylene glycol, ethylene glycol, butylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, pentylene glycol, hexylene glycol, propanediol, dipropylene glycol, ethoxydiglycol, methylpropanediol, isopentyldiol, and mixtures thereof. 
     
     
         26 . The topical composition according to  claim 23 , wherein the polyglycols are selected from the group consisting of polyethylene glycol, polypropylene glycol and mixtures thereof. 
     
     
         27 . The topical composition according to  claim 22 , wherein
 ibuprofen is in an amount from about 0.001% to about 20% by weight of the composition;   the poly(monostearoyl glycerol-co-succinate) polymer is in an amount from about 0.05% to about 20% by weight of the composition;   the lower alcohol is in an amount from about 5% to about 80% by weight of the composition; and   the co-solvent is in an amount from about 1% to about 50% by weight of the composition.   
     
     
         28 . The topical composition according to  claim 27 , wherein
 ibuprofen is in an amount from about 0.01% to about 10% by weight of the composition;   the poly(monostearoyl glycerol-co-succinate) polymer is in an amount from about 1% to about 10% by weight of the composition;   the lower alcohol is in an amount from about 5% to about 40% by weight of the composition; and   the co-solvent is in an amount from about 5% to about 40% by weight of the composition.   
     
     
         29 . The topical composition according to  claim 26 , wherein
 ibuprofen is in an amount from about 1% to about 5% by weight of the composition;   the poly(monostearoyl glycerol-co-succinate) polymer is an amount from about 1% to about 5% by weight of the composition;   the lower alcohol is an amount from about 10% to about 30% by weight of the composition; and   the co-solvent is in an amount from about 10% to about 20% by weight of the composition.   
     
     
         30 . The topical composition according to  claim 26 , wherein the co-solvent is selected from the group consisting of glycerin, pentylene glycol and mixtures thereof. 
     
     
         31 . A topical composition comprising
 ibuprofen in an amount from about 1% to about 5% by weight of the composition;   a poly(monostearoyl glycerol-co-succinate) polymer in an amount from about 1% to about 5% by weight of the composition;   ethyl alcohol in an amount from about 15% to about 25% by weight of the composition; and   a co-solvent in an amount from about 5% to about 40% by weight of the composition.   
     
     
         32 . A topical composition according to  claim 31 , wherein the co-solvent is selected from the group consisting of glycerin, pentylene glycol and mixtures thereof.