Orally dispersible tablet

Abstract

The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture.

1 . A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. 
     
     
         2 . The rapidly disintegrating preparation according to  claim 1 , wherein the granules comprising a medicament further contains a binder. 
     
     
         3 . The rapidly disintegrating preparation according to  claim 1 , wherein the granules comprising a medicament further contains a masking agent. 
     
     
         4 . The rapidly disintegrating preparation according to  claim 1 , wherein the granules comprising a medicament further contains a solubilizer. 
     
     
         5 . The preparation according to  claim 1 , which is for oral-mucosal absorption. 
     
     
         6 . The preparation according to  claim 5 , wherein the medicament is (S)—N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide. 
     
     
         7 . The preparation according to  claim 5 , which is a tablet. 
     
     
         8 . A method of producing a rapidly disintegrating preparation, comprising a step of producing granules comprising a medicament,
 a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules, and   a step of mixing the coated granules with a disintegrant and molding the mixture.   
     
     
         9 .- 33 . (canceled)