Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System

Abstract

Method and apparatus for providing calibration of analyte sensor including applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured response is provided

1 . (canceled) 
     
     
         2 . A system comprising:
 means for obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;   means for determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and   means for assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend;   further comprising means for generating an alert signal responsive to a comparison of the at least one metric assessing the underlying trend with at least one predetermined threshold.   
     
     
         3 . A system comprising:
 means for obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;   means for determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and   means for assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend;   wherein the means for assessing the reliability of the at least one sensor signal comprises means for comparing the at least one metric assessing the underlying trend with at least a first predetermined threshold and a second predetermined threshold.   
     
     
         4 . A system comprising:
 means for obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;   means for determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and   means for assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend;   further comprising:   means for acquiring the at least one sensor signal from one or more subcutaneous glucose sensors, wherein the means for determine the at least one metric assessing the underlying trend reflects an apparent reliability of the at least one sensor signal that is acquired from the one or more subcutaneous glucose sensors.