Method of destroying and preventing bacterial and fungal biofilm by amino acid infusion

Abstract

Disclosed is a method comprising the administration of a 3% amino acid and 3% glycerin solution for the use of prevention and disruption of bacterial biofilms. Also disclosed is method comprising the administration of L-cysteine 0.4 g per 100 ml for the prevention and destruction of fungal biofilms.

1 . A method of preventing formation of and/or destroying a bacterial biofilm comprising administering a solution of 3% glycerin and a total of 3% amino acids, wherein the step of administering comprises irrigating a wound with the solution, nasal irrigation with the solution, orally swishing and spitting, intravenous infusion, or applying a compress moistened with the solution to the wound. 
     
     
         2 . The method of  claim 1 , wherein the solution comprises a total isoleucine at 0.21 g per 100 ml, Leucine at 0.27 g per 100 ml, Lysine at 0.22 g per 100 ml, Methionine at 0.16 g per 100 ml, Phenylalanine at 0.17 g per 100 ml, Tryptophan at 0.046 g per 100 ml, Valine at 0.2 g per 100 ml, Alanine at 0.21 g per 100 ml, Arginine at 0.29 g per 100 ml, Histidine at 0.085 g per 100 ml, Proline at 0.34 g per 100 ml, Serine at 0.18 g per 100 ml, Glycine at 0.42 g per 100 ml, Threonine at 0.12 g per 100 ml, and L-cysteine at 0.014 g or less per 100 ml. 
     
     
         3 . The method of  claim 1 , wherein the solution is ProcalAmine®. 
     
     
         4 . The method of  claim 1 , wherein the step of administering comprises applying a compress moistened with the solution to the wound for 48 hours. 
     
     
         5 . The method of  claim 1 , wherein the method of administration is by nasally irrigating a wound with the solution of 3% amino acids and 3% glycerin. 
     
     
         6 . The method of  claim 1 , wherein the biofilm comprises  Staphylacoccus aureus.    
     
     
         7 . The method of  claim 1 , wherein the method of administration is swishing and spitting the solution orally. 
     
     
         8 . A method of treating a fungal biofilm in an animal comprising administering a solution comprising L-cysteine. 
     
     
         9 . The method of  claim 8 , wherein the step of administration is performed intravenously, topically, orally, or intranasally. 
     
     
         10 . The method of  claim 8 , wherein the composition further comprises aspartic acid and/or glutamic acid. 
     
     
         11 . The method of  claim 8 , wherein the composition further comprises one or a combination of: isoleucine, leucine, lysine, methionine, threonine, valine, alanine, arginine, histidine, proline and serine. 
     
     
         12 . (canceled) 
     
     
         13 . The method of  claim 8 , wherein the biofilm comprises  Candida albicans.    
     
     
         14 . The method of  claim 8 , wherein the step of administering comprises exposing the biofilm to a compress moistened with the solution. 
     
     
         15 . A method of preventing formation of a fungal biofilm in an animal comprising administering to the animal a solution comprising L-cysteine. 
     
     
         16 . The method of  claim 15 , wherein the step of administration is performed intravenously, topically or orally. 
     
     
         17 . The method of  claim 15 , wherein the composition further comprises aspartic acid and/or glutamic acid. 
     
     
         18 . The method of  claim 15 , wherein the composition further comprises one or a combination of: isoleucine, leucine, lysine, methionine, threonine, valine, alanine, arginine, histidine, proline and serine. 
     
     
         19 . (canceled) 
     
     
         20 . The method of  claim 15 , wherein the biofilm comprises  Candida albicans.    
     
     
         21 . The method of  claim 15 , wherein the step of administering comprises exposing the solution to the biofilm orally by swishing and splitting. 
     
     
         22 . A method of treating or preventing sinusitis in an animal subject comprising administering to the animal a composition comprising ProcalAmine®. 
     
     
         23 . The method of  claim 22 , wherein the animal is a human.