US2017042711A1PendingUtilityA1

Polymeric stent and laser system for manufacturing the same

Assignee: KIM HYUNG-ILPriority: Feb 26, 2014Filed: Oct 31, 2016Published: Feb 16, 2017
Est. expiryFeb 26, 2034(~7.6 yrs left)· nominal 20-yr term from priority
B23K 2103/42B23K 2101/02A61F 2240/001B23K 26/0676A61F 2002/91533B29K 2067/046A61F 2/82B23K 26/0624B29C 2035/0838B29K 2995/006B23K 26/402A61F 2210/0004A61F 2002/91575A61F 2002/91583A61F 2002/91541B29C 35/0805B23K 26/38B23K 2103/50B29C 59/165A61F 2/915B29C 35/08B29L 2031/7532B23K 2203/42
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Claims

Abstract

Methods of manufacturing polymeric stents by forming a pattern on a polylactic acid tube using a second harmonic generator laser and polylactic acid polymeric stents having a pattern formed using a second harmonic generator laser.

Claims

exact text as granted — not AI-modified
1 - 13 . (canceled) 
     
     
         14 . A polylactic acid polymeric stent, wherein the polylactic acid polymeric stent has a pattern that is cut using a second harmonic generator laser in which a wavelength of 940 nm to 1,552 nm is converted,
 wherein the second harmonic generator laser has a pulse width of 1 fs to 900 fs and a repetition rate of 2 kHz to 200 kHz, and   wherein the polylactic acid polymeric stent has a variation in polydispersity index (PDI) of 20% or less, as represented by the following Equation 1:   
       
         
           
             
               
                 
                   
                     
                       
                         Variation 
                          
                         
                             
                         
                          
                         in 
                          
                         
                             
                         
                          
                         Polydispersity 
                          
                         
                             
                         
                          
                         Index 
                          
                         
                             
                         
                          
                         
                           ( 
                           % 
                           ) 
                         
                       
                       = 
                       
                         
                           
                             B 
                             - 
                             A 
                           
                           A 
                         
                         × 
                         100 
                       
                     
                     , 
                   
                 
                 
                   
                     Equation 
                      
                     
                         
                     
                      
                     1 
                   
                 
               
             
           
         
         in Equation 1, 
         A is a polydispersity index of a polylactic acid polymeric stent before a pattern is cut, and 
         B is a polydispersity index of the polylactic acid polymeric stent after the pattern is cut. 
       
     
     
         15 . The polylactic acid polymeric stent of  claim 14 , wherein the polylactic acid polymeric stent has a polydisperity index of 1 to 2. 
     
     
         16 . The polylactic acid polymeric stent of  claim 14 , wherein a variation in average molecular weight of the polylactic acid polymeric stent represented by the following Equation 2 is 20% or less: 
       
         
           
             
               
                 
                   
                     
                       
                         Variation 
                          
                         
                             
                         
                          
                         in 
                          
                         
                             
                         
                          
                         Average 
                          
                         
                             
                         
                          
                         Molecular 
                          
                         
                             
                         
                          
                         Weight 
                          
                         
                             
                         
                          
                         
                           ( 
                           % 
                           ) 
                         
                       
                       = 
                       
                         
                           
                             C 
                             - 
                             D 
                           
                           C 
                         
                         × 
                         100 
                       
                     
                     , 
                   
                 
                 
                   
                     Equation 
                      
                     
                         
                     
                      
                     2 
                   
                 
               
             
           
         
         in Equation 2, 
         C is an average molecular weight of a polylactic acid polymeric stent before a pattern is cut, and 
         D is an average molecular weight of the polylactic acid polymeric stent after the pattern is cut. 
       
     
     
         17 . A polylactic acid polymeric stent, wherein the polylactic acid polymeric stent has a pattern that is cut using a second harmonic generator laser in which a wavelength of 940 nm to 1,552 nm is converted,
 wherein the second harmonic generator laser has a pulse width of 1 fs to 900 fs and a repetition rate of 2 kHz to 200 kHz, and   wherein the polylactic acid polymeric stent has a variation in average molecular weight of 20% or less, as represented by the following Equation 2:   
       
         
           
             
               
                 
                   
                     
                       
                         Variation 
                          
                         
                             
                         
                          
                         in 
                          
                         
                             
                         
                          
                         Average 
                          
                         
                             
                         
                          
                         Molecular 
                          
                         
                             
                         
                          
                         Weight 
                          
                         
                             
                         
                          
                         
                           ( 
                           % 
                           ) 
                         
                       
                       = 
                       
                         
                           
                             C 
                             - 
                             D 
                           
                           C 
                         
                         × 
                         100 
                       
                     
                     , 
                   
                 
                 
                   
                     Equation 
                      
                     
                         
                     
                      
                     2 
                   
                 
               
             
           
         
         in Equation 2, 
         C is an average molecular weight of a polylactic acid polymeric stent before a pattern is cut, and 
         D is an average molecular weight of the polylactic acid polymeric stent after the pattern is cut. 
       
     
     
         18 . A laser system for cutting a pattern on a polylactic acid tube, comprising:
 a laser that generates a first laser beam having a first wavelength between 940 nm to 1,552 nm;   a second harmonic generator through which the first laser beam passes to create a second laser beam with a second wavelength between 470 nm to 776 nm, wherein the second laser beam is adapted to cut the pattern on the polylactic acid tube; and   wherein the second harmonic generator laser has a pulse width of 1 fs to 900 fs and a repetition rate of 2 kHz to 200 kHz.   
     
     
         19 . The laser system of  claim 18 , wherein the first wavelength is between 1,000 nm to 1,100 nm. 
     
     
         20 . The laser system of  claim 18 , wherein the second wavelength is 500 nm to 550 nm. 
     
     
         21 . The laser system of  claim 18 , wherein the second harmonic generator laser is a neodymium-doped laser, a ytterbium-doped laser, an erbium-doped laser, or a hybrid fiber laser. 
     
     
         22 . The laser system of  claim 18 , wherein the power of the laser is between 0.1 W to 10 W before or after being converted into the second harmonic generator laser. 
     
     
         23 . The laser system of  claim 18 , wherein the spot size generated by the second harmonic generator laser is between about 1 μm to 50 μm. 
     
     
         24 . The laser system of  claim 18 , wherein the second harmonic generator laser has a pulse width of 1 fs to 10 fs. 
     
     
         25 . The laser system of  claim 18 , wherein the diameter of the polylactic acid tube is about 0.3× to about 1× of the inner diameter of a human blood vessel. 
     
     
         26 . The laser system of  claim 18 , wherein the diameter of the polylactic acid tube is about 2.5 mm to about 4.0 mm in diameter.

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